Associations among smoking status, lifestyle and lipoprotein subclasses

Alison Beauchamp, Andrew Tonkin, Anna Peeters, Rory Wolfe, Gavin Turrell, Linton Harriss, Graham Giles, Dallas English, Alicia Jenkins

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    Background: The relationship between cigarette smoking and cardiovascular disease is well established, yet the underlying mechanisms remain unclear. Although smokers have a more atherogenic lipid profile, this may be mediated by other lifestyle-related factors. Analysis of lipoprotein subclasses by the use of nuclear magnetic resonance spectroscopy (NMR) may improve characterisation of lipoprotein abnormalities. Objective: We used NMR spectroscopy to investigate the relationships between smoking status, lifestyle-related risk factors, and lipoproteins in a contemporary cohort. Methods: A total of 612 participants (360 women) aged 40-69 years at baseline (1990-1994) enrolled in the Melbourne Collaborative Cohort Study had plasma lipoproteins measured with NMR. Data were analysed separately by sex. Results: After adjusting for lifestyle-related risk factors, including alcohol and dietary intake, physical activity, and weight, mean total low-density lipoprotein (LDL) particle concentration was greater for female smokers than nonsmokers. Both medium- and small-LDL particle concentrations contributed to this difference. Total high-density lipoprotein (HDL) and large-HDL particle concentrations were lower for female smokers than nonsmokers. The proportion with low HDL particle number was greater for female smokers than nonsmokers. For men, there were few smoking-related differences in lipoprotein measures. Conclusion: Female smokers have a more atherogenic lipoprotein profile than nonsmokers. This difference is independent of other lifestyle-related risk factors. Lipoprotein profiles did not differ greatly between male smokers and nonsmokers.

    Original languageEnglish
    Pages (from-to)522-530
    Number of pages9
    JournalJournal of Clinical Lipidology
    Issue number6
    Publication statusPublished - Nov 2010


    • Atherosclerosis
    • Lifestyle
    • Lipoproteins
    • Smoking
    • Spectroscopy


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