Associations between adipokines and obesity-related cancer

Gilberto Paz-Filho, Ee Lyn Lim, Ma-Li Wong, Julio Licinio

    Research output: Contribution to journalArticle

    121 Citations (Scopus)

    Abstract

    There is increasing evidence that obesity may have pathophysiological effects that extend beyond its well-known co-morbidities; in particular its role in cancer has received considerable epidemiological support. As adipose tissue becomes strongly established as an endocrine organ, two of its most abundant and most investigated adipokines, leptin and adiponectin, are also taken beyond their traditional roles in energy homeostasis, and are implicated as mediators of the effects of obesity on cancer development. This review examines these dipokines in relation to the prostate, breast, colorectal, thyroid, renal, pancreatic, endometrial and oesophageal cancers, and how they may orchestrate the influence of obesity on the development of these malignancies.

    Original languageEnglish
    Pages (from-to)1634-1650
    Number of pages17
    JournalFrontiers in Bioscience: Landmark Edition
    Volume16
    Issue number5
    DOIs
    Publication statusPublished - 1 Jan 2011

    Keywords

    • Adipocytokine
    • Adipokine
    • Adiponectin
    • Cancer
    • Leptin
    • Obesity
    • Review

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