TY - JOUR
T1 - Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders
T2 - A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches
AU - Yao, Shuyang
AU - Kuja-Halkola, Ralf
AU - Martin, Joanna
AU - Lu, Yi
AU - Lichtenstein, Paul
AU - Norring, Claes
AU - Birgegård, Andreas
AU - Yilmaz, Zeynep
AU - Hübel, Christopher
AU - Watson, Hunna
AU - Baker, Jessica
AU - Almqvist, Catarina
AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium
AU - Thornton, Laura M.
AU - Magnusson, Patrik K.
AU - Bulik, Cynthia M.
AU - Larsson, Henrik
AU - Adan, Roger
AU - Ando, Tetsuya
AU - Bergen, Andrew
AU - Berrettini, Wade
AU - Boni, Claudette
AU - Boraska Perica, Vesna
AU - Brandt, Harry
AU - Burghardt, Roland
AU - Cassina, Matteo
AU - Cesta, Carolyn
AU - Clementi, Maurizio
AU - Coleman, Joni
AU - Cone, Roger
AU - Courtet, Philippe
AU - Crawford, Steven
AU - Crow, Scott
AU - Crowley, James
AU - Danner, Unna
AU - Davis, Oliver
AU - de Zwaan, Martina
AU - Dedoussis, George
AU - Degortes, Daniela
AU - DeSocio, Janiece
AU - Dick, Danielle
AU - Dikeos, Dimitris
AU - Dmitrzak-Weglarz, Monika
AU - Docampo, Elisa
AU - Egberts, Karin
AU - Ehrlich, Stefan
AU - Escaramís, Geòrgia
AU - Esko, Tõnu
AU - Estivill, Xavier
AU - Favaro, Angela
AU - Fernández-Aranda, Fernando
AU - Fichter, Manfred
AU - Finan, Chris
AU - Fischer, Krista
AU - Föcker, Manuel
AU - Foretova, Lenka
AU - Forzan, Monica
AU - Franklin, Christopher
AU - Gaspar, Héléna
AU - Gonidakis, Fragiskos
AU - Gorwood, Philip
AU - Gratacos, Monica
AU - Guillaume, Sébastien
AU - Guo, Yiran
AU - Hakonarson, Hakon
AU - Halmi, Katherine
AU - Hatzikotoulas, Konstantinos
AU - Hauser, Joanna
AU - Hebebrand, Johannes
AU - Helder, Sietske
AU - Hendriks, Judith
AU - Herpertz-Dahlmann, Beate
AU - Herzog, Wolfgang
AU - Hilliard, Christopher
AU - Hinney, Anke
AU - Huckins, Laura
AU - Hudson, James
AU - Huemer, Julia
AU - Imgart, Hartmut
AU - Inoko, Hidetoshi
AU - Jiménez-Murcia, Susana
AU - Johnson, Craig
AU - Jordan, Jenny
AU - Juréus, Anders
AU - Kalsi, Gursharan
AU - Kaminska, Debora
AU - Kaplan, Allan
AU - Kaprio, Jaakko
AU - Karhunen, Leila
AU - Karwautz, Andreas
AU - Kas, Martien
AU - Kaye, Walter
AU - Kennedy, James
AU - Kennedy, Martin
AU - Keski-Rahkonen, Anna
AU - Kiezebrink, Kirsty
AU - Kim, Youl Ri
AU - Klump, Kelly
AU - Knudsen, Gun Peggy
AU - Koeleman, Bobby
AU - Koubek, Doris
AU - La Via, Maria
AU - Landén, Mikael
AU - Levitan, Robert
AU - Li, Dong
AU - Lilenfeld, Lisa
AU - Lissowska, Jolanta
AU - Magistretti, Pierre
AU - Maj, Mario
AU - Mannik, Katrin
AU - Martin, Nicholas
AU - McDevitt, Sara
AU - McGuffin, Peter
AU - Merl, Elisabeth
AU - Metspalu, Andres
AU - Meulenbelt, Ingrid
AU - Micali, Nadia
AU - Mitchell, James
AU - Mitchell, Karen
AU - Monteleone, Palmiero
AU - Monteleone, Alessio Maria
AU - Mortensen, Preben
AU - Munn-Chernoff, Melissa
AU - Nacmias, Benedetta
AU - Nilsson, Ida
AU - Ntalla, Ioanna
AU - O'Toole, Julie
AU - Pantel, Jacques
AU - Papezova, Hana
AU - Parker, Richard
AU - Rabionet, Raquel
AU - Raevuori, Anu
AU - Rajewski, Andrzej
AU - Ramoz, Nicolas
AU - Rayner, N. William
AU - Reichborn-Kjennerud, Ted
AU - Ricca, Valdo
AU - Ripke, Stephan
AU - Ritschel, Franziska
AU - Roberts, Marion
AU - Rotondo, Alessandro
AU - Rybakowski, Filip
AU - Santonastaso, Paolo
AU - Scherag, André
AU - Schmidt, Ulrike
AU - Schork, Nicholas
AU - Schosser, Alexandra
AU - Seitz, Jochen
AU - Slachtova, Lenka
AU - Slagboom, P. Eline
AU - Slof-Op't Landt, Margarita
AU - Slopien, Agnieszka
AU - Smith, Tosha
AU - Sorbi, Sandro
AU - Strengman, Eric
AU - Strober, Michael
AU - Sullivan, Patrick
AU - Szatkiewicz, Jin
AU - Szeszenia-Dabrowska, Neonila
AU - Tachmazidou, Ioanna
AU - Tenconi, Elena
AU - Tortorella, Alfonso
AU - Tozzi, Federica
AU - Treasure, Janet
AU - Tsitsika, Artemis
AU - Tziouvas, Konstantinos
AU - van Elburg, Annemarie
AU - van Furth, Eric
AU - Wade, Tracey
AU - Wagner, Gudrun
AU - Walton, Esther
AU - Woodside, D. Blake
AU - Zeggini, Eleftheria
AU - Zerwas, Stephanie
AU - Zipfel, Stephan
AU - Alfredsson, Lars
AU - Andreassen, Ole
AU - Aschauer, Harald
AU - Barrett, Jeffrey
AU - Bencko, Vladimir
AU - Carlberg, Laura
AU - Cichon, Sven
AU - Cohen-Woods, Sarah
AU - Dina, Christian
AU - Ding, Bo
AU - Espeseth, Thomas
AU - Floyd, James
AU - Gallinger, Steven
AU - Gambaro, Giovanni
AU - Giegling, Ina
AU - Herms, Stefan
AU - Janout, Vladimir
AU - Julià, Antonio
AU - Klareskog, Lars
AU - Le Hellard, Stephanie
AU - Leboyer, Marion
AU - Lundervold, Astri
AU - Marsal, Sara
AU - Mattingsdal, Morten
AU - Navratilova, Marie
AU - Ophoff, Roel
AU - Palotie, Aarno
AU - Pinto, Dalila
AU - Ripatti, Samuli
AU - Rujescu, Dan
AU - Scherer, Stephen
AU - Scott, Laura
AU - Sladek, Robert
AU - Soranzo, Nicole
AU - Southam, Lorraine
AU - Steen, Vidar
AU - Wichmann, H. Erich
AU - Widen, Elisabeth
AU - Breen, Gerome
PY - 2019/10/15
Y1 - 2019/10/15
N2 - Background: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. Methods: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Results: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. Conclusions: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
AB - Background: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently co-occur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. Methods: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). Results: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. Conclusions: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
KW - ADHD
KW - Anorexia nervosa
KW - Bulimia nervosa
KW - Eating disorders
KW - Genetic epidemiology
KW - Polygenic risk score
UR - http://www.scopus.com/inward/record.url?scp=85068526535&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2019.04.036
DO - 10.1016/j.biopsych.2019.04.036
M3 - Article
C2 - 31301758
AN - SCOPUS:85068526535
VL - 86
SP - 577
EP - 586
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 8
ER -