Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis

Panagiotis Paliogiannis, Rosanna Satta, Giovanni Deligia, Giuseppina Farina, Stefania Bassu, Arduino A Mangoni, Ciriaco Carru, Angelo Zinellu

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

The diagnosis of psoriasis, an immune-mediated disease that affects 2% of the population in Western countries, is largely based on history and clinical examination. The aim of this systematic review and meta-analysis was to investigate the associations between the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence and clinical severity of psoriasis. A systematic literature search was conducted in PubMed, Web of Science, and Scopus, from inception to January 2018. Twelve case–control studies enrolling 1067 psoriasis patients (537 males and 530 females) and 799 healthy controls (404 males and 395 females) were included in the meta-analysis. The NLR was evaluated in all the studies, while the PLR was assessed in four studies. Pooled results showed that both the NLR and the PLR values were significantly higher in patients with psoriasis (SMD = 0.69, 95% CI 0.53–1.85, p < 0.001, and SMD = 0.40, 95% CI 0.12–0.68, p = 0.006, respectively). There were no significant differences in NLR values according to the severity of disease (p = 0.52). The NLR and the PLR are significantly associated with the presence, but not with the severity, of psoriasis. Further studies are required to determine the additional utility of these haematological indexes in the diagnosis of psoriasis.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalCLINICAL AND EXPERIMENTAL MEDICINE
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • psoriasis
  • immune-mediated disease
  • neutrophil-to-lymphocyte ratio (NLR)
  • Psoriasis
  • Lymphocytes
  • NLR
  • Neutrophils
  • PLR
  • Inflammation
  • Platelets

Fingerprint Dive into the research topics of 'Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this