TY - JOUR
T1 - Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: A meta-analysis
AU - Fox, Caroline S.
AU - Matsushita, Kunihiro
AU - Woodward, Mark
AU - Bilo, Henk J.G.
AU - Chalmers, John
AU - Lambers Heerspink, Hiddo J.
AU - Lee, Brian J.
AU - Perkins, Robert M.
AU - Rossing, Peter
AU - Sairenchi, Toshimi
AU - Tonelli, Marcello
AU - Vassalotti, Joseph A.
AU - Yamagishi, Kazumasa
AU - Coresh, Josef
AU - De Jong, Paul E.
AU - Wen, Chi Pang
AU - Nelson, Robert G.
AU - Chronic Kidney Disease Prognosis Consortium
PY - 2012/11
Y1 - 2012/11
N2 - Background Chronic kidney disease is characterised by low estimated glomerular fi ltration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modifi ed by diabetes is unknown. Methods We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. Findings We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and highrisk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and highrisk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8•5 years (SD 5•0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths occurred from cardiovascular disease during a mean follow-up of 9•2 years (SD 4•9). In the general and high-risk cohorts, mortality risks were 1•2-1•9 times higher for participants with diabetes than for those without diabetes across the ranges of eGFR and albumin-tocreatinine ratio (ACR). With fi xed eGFR and ACR reference points in the diabetes and no diabetes groups, HR of mortality outcomes according to lower eGFR and higher ACR were much the same in participants with and without diabetes (eg, for all-cause mortality at eGFR 45 mL/min per 1•73 m2 [vs 95 mL/min per 1•73 m2], HR 1•35; 95% CI 1•18-1•55; vs 1•33; 1•19-1•48 and at ACR 30 mg/g [vs 5 mg/g], 1•50; 1•35-1•65 vs 1•52; 1•38-1•67). The overall interactions were not signifi cant. We identifi ed much the same fi ndings for ESRD in the chronic kidney disease cohorts. Interpretation Despite higher risks for mortality and ESRD in diabetes, the relative risks of these outcomes by eGFR and ACR are much the same irrespective of the presence or absence of diabetes, emphasising the importance of kidney disease as a predictor of clinical outcomes. Funding US National Kidney Foundation.
AB - Background Chronic kidney disease is characterised by low estimated glomerular fi ltration rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these risks are modifi ed by diabetes is unknown. Methods We did a meta-analysis of studies selected according to Chronic Kidney Disease Prognosis Consortium criteria. Data transfer and analyses were done between March, 2011, and June, 2012. We used Cox proportional hazards models to estimate the hazard ratios (HR) of mortality and end-stage renal disease (ESRD) associated with eGFR and albuminuria in individuals with and without diabetes. Findings We analysed data for 1 024 977 participants (128 505 with diabetes) from 30 general population and highrisk cardiovascular cohorts and 13 chronic kidney disease cohorts. In the combined general population and highrisk cohorts with data for all-cause mortality, 75 306 deaths occurred during a mean follow-up of 8•5 years (SD 5•0). In the 23 studies with data for cardiovascular mortality, 21 237 deaths occurred from cardiovascular disease during a mean follow-up of 9•2 years (SD 4•9). In the general and high-risk cohorts, mortality risks were 1•2-1•9 times higher for participants with diabetes than for those without diabetes across the ranges of eGFR and albumin-tocreatinine ratio (ACR). With fi xed eGFR and ACR reference points in the diabetes and no diabetes groups, HR of mortality outcomes according to lower eGFR and higher ACR were much the same in participants with and without diabetes (eg, for all-cause mortality at eGFR 45 mL/min per 1•73 m2 [vs 95 mL/min per 1•73 m2], HR 1•35; 95% CI 1•18-1•55; vs 1•33; 1•19-1•48 and at ACR 30 mg/g [vs 5 mg/g], 1•50; 1•35-1•65 vs 1•52; 1•38-1•67). The overall interactions were not signifi cant. We identifi ed much the same fi ndings for ESRD in the chronic kidney disease cohorts. Interpretation Despite higher risks for mortality and ESRD in diabetes, the relative risks of these outcomes by eGFR and ACR are much the same irrespective of the presence or absence of diabetes, emphasising the importance of kidney disease as a predictor of clinical outcomes. Funding US National Kidney Foundation.
UR - http://www.scopus.com/inward/record.url?scp=84868540565&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(12)61350-6
DO - 10.1016/S0140-6736(12)61350-6
M3 - Review article
C2 - 23013602
AN - SCOPUS:84868540565
SN - 0140-6736
VL - 380
SP - 1662
EP - 1673
JO - The Lancet
JF - The Lancet
IS - 9854
ER -
