TY - JOUR
T1 - Associations of serum adiponectin with markers of cardio-metabolic disease risk in Indigenous Australian adults with good health, diabetes and chronic kidney disease
AU - Hughes, J. T.
AU - O'Dea, K.
AU - Piera, K.
AU - Barzi, F.
AU - Cass, A.
AU - Hoy, W. E.
AU - MacIsaac, R. J.
AU - Maple-Brown, L. J.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - The higher serum adiponectin concentrations observed in females are often attributed to differences in adiposity or sex hormones. There is little data describing adiponectin in Indigenous Australians, and no studies examining its association with cardio-metabolic disease risk markers and chronic kidney disease (CKD). Aim To describe the relationship of serum adiponectin with cardio-metabolic disease risk markers and kidney function in a community-based sample of Indigenous Australian adults, with particular reference to sex-specific differences. Methods A cross-sectional analysis of a community-based volunteer sample of 548 Indigenous Australian adults (62% female), stratified into five cardio-metabolic risk groups ranging from good health (strata-1) to high cardio-metabolic risk and low measured glomerular filtration rate (mGFR, <60 ml/min/1.73 m2) (strata-5). We examined serum adiponectin concentrations with cardio-metabolic risk markers, albuminuria and mGFR. Results Indigenous Australian females had a lower than expected adiponectin concentration (3.5 μg/ml), which was higher than males in strata 1–4 (as in other populations), but not in strata-5 (mGFR < 60, p = 0.19), and higher leptin: adiponectin ratio than other populations (7.8 ng/μg – strata-1, healthy females; 12.2 ng/μg – strata-3, females with diabetes and mGFR ≥ 90). Female-gender, HDL-cholesterol (positive), mGFR and waist: hip ratio (WHR) (inverse) were independently associated with log-adiponectin when mGFR ≥ 60; when mGFR < 60, female-gender was associated with 0.27 units lower log-adiponectin. Conclusion Female-gender was not associated with higher adiponectin concentrations in Indigenous Australians with mGFR < 60 ml/min/1.73 m2. High WHR was frequent in both genders, and inversely associated with adiponectin. Longitudinal studies are needed to examine relationships of serum adiponectin, obesity and cardiovascular disease events in Indigenous Australians.
AB - The higher serum adiponectin concentrations observed in females are often attributed to differences in adiposity or sex hormones. There is little data describing adiponectin in Indigenous Australians, and no studies examining its association with cardio-metabolic disease risk markers and chronic kidney disease (CKD). Aim To describe the relationship of serum adiponectin with cardio-metabolic disease risk markers and kidney function in a community-based sample of Indigenous Australian adults, with particular reference to sex-specific differences. Methods A cross-sectional analysis of a community-based volunteer sample of 548 Indigenous Australian adults (62% female), stratified into five cardio-metabolic risk groups ranging from good health (strata-1) to high cardio-metabolic risk and low measured glomerular filtration rate (mGFR, <60 ml/min/1.73 m2) (strata-5). We examined serum adiponectin concentrations with cardio-metabolic risk markers, albuminuria and mGFR. Results Indigenous Australian females had a lower than expected adiponectin concentration (3.5 μg/ml), which was higher than males in strata 1–4 (as in other populations), but not in strata-5 (mGFR < 60, p = 0.19), and higher leptin: adiponectin ratio than other populations (7.8 ng/μg – strata-1, healthy females; 12.2 ng/μg – strata-3, females with diabetes and mGFR ≥ 90). Female-gender, HDL-cholesterol (positive), mGFR and waist: hip ratio (WHR) (inverse) were independently associated with log-adiponectin when mGFR ≥ 60; when mGFR < 60, female-gender was associated with 0.27 units lower log-adiponectin. Conclusion Female-gender was not associated with higher adiponectin concentrations in Indigenous Australians with mGFR < 60 ml/min/1.73 m2. High WHR was frequent in both genders, and inversely associated with adiponectin. Longitudinal studies are needed to examine relationships of serum adiponectin, obesity and cardiovascular disease events in Indigenous Australians.
KW - Adiponectin
KW - Chronic kidney disease
KW - Diabetes
KW - Indigenous
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84949675110&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/545205
UR - http://purl.org/au-research/grants/NHMRC/490348
UR - http://purl.org/au-research/grants/NHMRC/1092576
UR - http://purl.org/au-research/grants/NHMRC/605837
UR - http://purl.org/au-research/grants/NHMRC/1078477
UR - http://purl.org/au-research/grants/NHMRC/490307
U2 - 10.1016/j.orcp.2015.11.008
DO - 10.1016/j.orcp.2015.11.008
M3 - Article
C2 - 26669799
AN - SCOPUS:84949675110
SN - 1871-403X
VL - 10
SP - 659
EP - 672
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 6
ER -