Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study

Luke E. Grzeskowiak, Lisa G. Smithers, Jessica A. Grieger, Tina Bianco-Miotto, Shalem Y. Leemaqz, Vicki L. Clifton, Lucilla Poston, Lesley M. McCowan, Louise C. Kenny, Jenny Myers, James J. Walker, Robert J. Norman, Gus A. Dekker, Claire T. Roberts

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Abstract

Asthma is a common chronic disease affecting the lives of reproductive age women and is associated with 8–13% of pregnancies [1]. While maternal asthma has been consistently associated with significant perinatal morbidities and mortality [2, 3], impacts on fertility are conflicting. In light of limited and conflicting evidence, the aim of this study was to examine the impact of asthma and asthma medication use on fecundability and time to pregnancy.

In conclusion, the management of asthma with SABAs was associated with reduced fertility, whereas the management of asthma with ICS with or without LABAs was not. These findings support appropriate management of asthma with ICS preventer medications to ensure optimal asthma control. Women with asthma planning a pregnancy should be encouraged to continue taking their preventer medications.
Original languageEnglish
Article number1702035
Number of pages4
JournalEuropean Respiratory Journal
Volume51
Issue number2
DOIs
Publication statusPublished - 21 Feb 2018
Externally publishedYes

Keywords

  • asthma
  • time to pregnancy
  • treatment

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    Grzeskowiak, L. E., Smithers, L. G., Grieger, J. A., Bianco-Miotto, T., Leemaqz, S. Y., Clifton, V. L., Poston, L., McCowan, L. M., Kenny, L. C., Myers, J., Walker, J. J., Norman, R. J., Dekker, G. A., & Roberts, C. T. (2018). Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study. European Respiratory Journal, 51(2), [1702035]. https://doi.org/10.1183/13993003.02035-2017