Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study

Luke E. Grzeskowiak; Lisa G. Smithers; Jessica A. Grieger; Tina Bianco-Miotto; Shalem Y. Leemaqz; Vicki L. Clifton; Lucilla Poston; Lesley M. McCowan; Louise C. Kenny; Jenny Myers; James J. Walker; Robert J. Norman; Gus A. Dekker; Claire T. Roberts

doi:10.1183/13993003.02035-2017

Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study

Luke E. Grzeskowiak, Lisa G. Smithers, Jessica A. Grieger, Tina Bianco-Miotto, Shalem Y. Leemaqz, Vicki L. Clifton, Lucilla Poston, Lesley M. McCowan, Louise C. Kenny, Jenny Myers, James J. Walker, Robert J. Norman, Gus A. Dekker, Claire T. Roberts

Research output: Contribution to journal › Letter

8 Citations (Scopus)

Abstract

Asthma is a common chronic disease affecting the lives of reproductive age women and is associated with 8–13% of pregnancies [1]. While maternal asthma has been consistently associated with significant perinatal morbidities and mortality [2, 3], impacts on fertility are conflicting. In light of limited and conflicting evidence, the aim of this study was to examine the impact of asthma and asthma medication use on fecundability and time to pregnancy.

In conclusion, the management of asthma with SABAs was associated with reduced fertility, whereas the management of asthma with ICS with or without LABAs was not. These findings support appropriate management of asthma with ICS preventer medications to ensure optimal asthma control. Women with asthma planning a pregnancy should be encouraged to continue taking their preventer medications.

Original language	English
Article number	1702035
Number of pages	4
Journal	European Respiratory Journal
Volume	51
Issue number	2
DOIs	https://doi.org/10.1183/13993003.02035-2017
Publication status	Published - 21 Feb 2018
Externally published	Yes

Keywords

asthma
time to pregnancy
treatment

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Grzeskowiak, L. E., Smithers, L. G., Grieger, J. A., Bianco-Miotto, T., Leemaqz, S. Y., Clifton, V. L., Poston, L., McCowan, L. M., Kenny, L. C., Myers, J., Walker, J. J., Norman, R. J., Dekker, G. A., & Roberts, C. T. (2018). Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study. European Respiratory Journal, 51(2), [1702035]. https://doi.org/10.1183/13993003.02035-2017

Grzeskowiak, Luke E. ; Smithers, Lisa G. ; Grieger, Jessica A. ; Bianco-Miotto, Tina ; Leemaqz, Shalem Y. ; Clifton, Vicki L. ; Poston, Lucilla ; McCowan, Lesley M. ; Kenny, Louise C. ; Myers, Jenny ; Walker, James J. ; Norman, Robert J. ; Dekker, Gus A. ; Roberts, Claire T. / Asthma treatment impacts time to pregnancy : Evidence from the international SCOPE study. In: European Respiratory Journal. 2018 ; Vol. 51, No. 2.

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title = "Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study",

abstract = "Asthma is a common chronic disease affecting the lives of reproductive age women and is associated with 8–13% of pregnancies [1]. While maternal asthma has been consistently associated with significant perinatal morbidities and mortality [2, 3], impacts on fertility are conflicting. In light of limited and conflicting evidence, the aim of this study was to examine the impact of asthma and asthma medication use on fecundability and time to pregnancy.In conclusion, the management of asthma with SABAs was associated with reduced fertility, whereas the management of asthma with ICS with or without LABAs was not. These findings support appropriate management of asthma with ICS preventer medications to ensure optimal asthma control. Women with asthma planning a pregnancy should be encouraged to continue taking their preventer medications.",

keywords = "asthma, time to pregnancy, treatment",

author = "Grzeskowiak, {Luke E.} and Smithers, {Lisa G.} and Grieger, {Jessica A.} and Tina Bianco-Miotto and Leemaqz, {Shalem Y.} and Clifton, {Vicki L.} and Lucilla Poston and McCowan, {Lesley M.} and Kenny, {Louise C.} and Jenny Myers and Walker, {James J.} and Norman, {Robert J.} and Dekker, {Gus A.} and Roberts, {Claire T.}",

year = "2018",

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day = "21",

doi = "10.1183/13993003.02035-2017",

language = "English",

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Grzeskowiak, LE, Smithers, LG, Grieger, JA, Bianco-Miotto, T, Leemaqz, SY, Clifton, VL, Poston, L, McCowan, LM, Kenny, LC, Myers, J, Walker, JJ, Norman, RJ, Dekker, GA & Roberts, CT 2018, 'Asthma treatment impacts time to pregnancy: Evidence from the international SCOPE study', European Respiratory Journal, vol. 51, no. 2, 1702035. https://doi.org/10.1183/13993003.02035-2017

Asthma treatment impacts time to pregnancy : Evidence from the international SCOPE study. / Grzeskowiak, Luke E.; Smithers, Lisa G.; Grieger, Jessica A.; Bianco-Miotto, Tina; Leemaqz, Shalem Y.; Clifton, Vicki L.; Poston, Lucilla; McCowan, Lesley M.; Kenny, Louise C.; Myers, Jenny; Walker, James J.; Norman, Robert J.; Dekker, Gus A.; Roberts, Claire T.

In: European Respiratory Journal, Vol. 51, No. 2, 1702035, 21.02.2018.

Research output: Contribution to journal › Letter

TY - JOUR

T1 - Asthma treatment impacts time to pregnancy

T2 - Evidence from the international SCOPE study

AU - Grzeskowiak, Luke E.

AU - Smithers, Lisa G.

AU - Grieger, Jessica A.

AU - Bianco-Miotto, Tina

AU - Leemaqz, Shalem Y.

AU - Clifton, Vicki L.

AU - Poston, Lucilla

AU - McCowan, Lesley M.

AU - Kenny, Louise C.

AU - Myers, Jenny

AU - Walker, James J.

AU - Norman, Robert J.

AU - Dekker, Gus A.

AU - Roberts, Claire T.

PY - 2018/2/21

Y1 - 2018/2/21

N2 - Asthma is a common chronic disease affecting the lives of reproductive age women and is associated with 8–13% of pregnancies [1]. While maternal asthma has been consistently associated with significant perinatal morbidities and mortality [2, 3], impacts on fertility are conflicting. In light of limited and conflicting evidence, the aim of this study was to examine the impact of asthma and asthma medication use on fecundability and time to pregnancy.In conclusion, the management of asthma with SABAs was associated with reduced fertility, whereas the management of asthma with ICS with or without LABAs was not. These findings support appropriate management of asthma with ICS preventer medications to ensure optimal asthma control. Women with asthma planning a pregnancy should be encouraged to continue taking their preventer medications.

AB - Asthma is a common chronic disease affecting the lives of reproductive age women and is associated with 8–13% of pregnancies [1]. While maternal asthma has been consistently associated with significant perinatal morbidities and mortality [2, 3], impacts on fertility are conflicting. In light of limited and conflicting evidence, the aim of this study was to examine the impact of asthma and asthma medication use on fecundability and time to pregnancy.In conclusion, the management of asthma with SABAs was associated with reduced fertility, whereas the management of asthma with ICS with or without LABAs was not. These findings support appropriate management of asthma with ICS preventer medications to ensure optimal asthma control. Women with asthma planning a pregnancy should be encouraged to continue taking their preventer medications.

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KW - time to pregnancy

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