ATG8 in single membranes:: Fresh players of endocytosis and acidic organelle quality control in cancer, neurodegeneration, and inflammation

Wang, B. Ben; Pirjo M. Apaja

doi:10.1016/j.bbrc.2025.151384

ATG8 in single membranes: Fresh players of endocytosis and acidic organelle quality control in cancer, neurodegeneration, and inflammation

Wang, B. Ben, Pirjo M. Apaja

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

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Abstract

Ubiquitin-like autophagy-related gene ATG8 proteins are typically associated with degradative quality control via canonical double-membrane macro-autophagosomes in the cell. ATG8 proteins have now stepped forward in non-canonical pathways in single membrane organelles. The growing interest in non-canonical ATG8 roles has been stimulated by recent links to human conditions, especially in the regulation of inflammation, neurodegeneration and cancers. Here, we summarize the evidence linking non-canonical ATG8s to human pathologies and the quality control of acidic V-ATPase-regulated organelles in the cell.

Original language	English
Article number	151384
Number of pages	10
Journal	Biochemical and Biophysical Research Communications
Volume	749
DOIs	https://doi.org/10.1016/j.bbrc.2025.151384
Publication status	Published - 16 Feb 2025

Bibliographical note

There is a corrigendum included at the end of this article

Keywords

Cancer
Endosome
Inflammation
Lysosome
Neurodegeneration
Organelle pH
Ubiquitin
Ubiquitin-like
V-ATPase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2025.151384Licence: CC BY-NC-ND

Published versionFinal published version, 2.6 MBLicence: CC BY-NC-ND

Cite this

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abstract = "Ubiquitin-like autophagy-related gene ATG8 proteins are typically associated with degradative quality control via canonical double-membrane macro-autophagosomes in the cell. ATG8 proteins have now stepped forward in non-canonical pathways in single membrane organelles. The growing interest in non-canonical ATG8 roles has been stimulated by recent links to human conditions, especially in the regulation of inflammation, neurodegeneration and cancers. Here, we summarize the evidence linking non-canonical ATG8s to human pathologies and the quality control of acidic V-ATPase-regulated organelles in the cell.",

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AU - Apaja, Pirjo M.

N1 - There is a corrigendum included at the end of this article

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KW - Inflammation

KW - Lysosome

KW - Neurodegeneration

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KW - Ubiquitin-like

KW - V-ATPase

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