Atrial fibrillation burden: an update - the need for a CHA2DS2-VASc-AFBurden score

Kathryn D. Tiver, Jing Quah, Anandaroop Lahiri, Anand N. Ganesan, Andrew D. McGavigan

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Atrial fibrillation (AF) is an established independent risk factor for stroke. Current guidelines regard AF as binary; either present or absent, with the decision for anti-coagulation driven by clinical variables alone. However, there are increasing data to support a biological gradient of AF burden and stroke risk, both in clinical and non-clinical AF phenotypes. As such, this raises the concept of combining AF burden assessment with a clinical risk score to refine and individualize the assessment of stroke risk in AF - the CHA2DS2VASc-AFBurden score. We review the published data supporting a biological gradient to try and construct a putative schema of risk attributable to AF burden.

Original languageEnglish
Pages (from-to)665-673
Number of pages9
JournalEP Europace
Issue number5
Publication statusPublished - 1 May 2021
Externally publishedYes


  • Atrial fibrillation
  • Atrial high rate episodes
  • Burden
  • Duration
  • Stroke
  • Systemic embolism


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