Atypical EEG complexity in autism spectrum conditions: A multiscale entropy analysis

Ana Catarino, Owen Churches, Simon Baron-Cohen, Alexandre Andrade, Howard Ring

    Research output: Contribution to journalArticlepeer-review

    135 Citations (Scopus)

    Abstract

    Objective: Intrinsic complexity subserves adaptability in biological systems. One recently developed measure of intrinsic complexity of biological systems is multiscale entropy (MSE). Autism spectrum conditions (ASC) have been described in terms of reduced adaptability at a behavioural level and by patterns of atypical connectivity at a neural level. Based on these observations we aimed to test the hypothesis that adults with ASC would show atypical intrinsic complexity of brain activity as indexed by MSE analysis of electroencephalographic (EEG) activity. Methods: We used MSE to assess the complexity of EEG data recorded from 15 participants with ASC and 15 typical controls, during a face and chair matching task. Results: Results demonstrate a reduction of EEG signal complexity in the ASC group, compared to typical controls, over temporo-parietal and occipital regions. No significant differences in EEG power spectra were observed between groups, indicating that changes in complexity values are not a reflection of changes in EEG power spectra. Conclusions: The results are consistent with a model of atypical neural integrative capacity in people with ASC. Significance: Results suggest that EEG complexity, as indexed by MSE measures, may also be a marker for disturbances in task-specific processing of information in people with autism.

    Original languageEnglish
    Pages (from-to)2375-2383
    Number of pages9
    JournalClinical Neurophysiology
    Volume122
    Issue number12
    DOIs
    Publication statusPublished - Dec 2011

    Keywords

    • Autism spectrum conditions
    • Complexity
    • Electroencephalography
    • Face perception
    • Multiscale entropy

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