Atypical Haemolytic Uraemic Syndrome Associated with Clostridium difficile Infection Successfully Treated with Eculizumab

Joshua M Inglis, Jeffrey A Barbara, Rajiv Juneja, Caroline Milton, George Passaris, Jordan Li

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    Abstract

    Clostridium difficile infection is a rare precipitant of atypical haemolytic uraemic syndrome (aHUS). A 46-year-old man presented with watery diarrhoea following an ileocaecal resection. He developed an acute kidney injury with anaemia, thrombocytopaenia, raised lactate dehydrogenase, low haptoglobin, and red cell fragments. Stool sample was positive for C. difficile toxin B. He became dialysis-dependent as his renal function continued to worsen despite treatment with empiric antibiotics and plasma exchange. The ADAMTS13 level was normal consistent with a diagnosis of aHUS. The commencement of eculizumab led to the resolution of haemolysis and stabilisation of haemoglobin and platelets with an improvement in renal function.
    Original languageEnglish
    Article number1759138
    Number of pages5
    JournalCase Reports in Nephrology
    Volume2018
    DOIs
    Publication statusE-pub ahead of print - 2018

    Bibliographical note

    Published online 2018 May 10

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