TY - JOUR
T1 - Audible clicking on blinking
T2 - an adverse effect of topical prostaglandin analogue medication
AU - Abedi, Farshad
AU - Chappell, Angela
AU - Craig, Jamie
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The prostaglandin analogues (PGAs), latanoprost, bimatoprost and travoprost have significantly changed the pharmacological management of glaucoma and ocular hypertension. Based on their good efficacy with only once daily dosing, and their low rate of systemic side effects, they are currently the mainstay of treatment.1 Therefore, it is important that medical practitioners are aware of their potential adverse effects. Conjunctival hyperaemia, iris pigmentation, hypertrichosis, periocular skin pigmentation, cystoid macular oedema, iris cysts, deepening of the upper eyelid sulci, sunken eye appearance and periorbital fat atrophy have been reported.2-4 Kucukevcilioglu et al. published their observations of 105 patients treated with PGAs in one eye for more than 1 month. The rate of prostaglandin‐associated periorbitopathy was 93.3%, 41.4% and 70% in the bimatoprost, latanoprost and travoprost groups.4 An Australian group recently reported audible blinking after topical bimatoprost for 3 years followed by travoprost 0.0004%/timolol 0.5% for 2 years.5 In this study, we present a case with clearly audible clicking sounds from both eyelids associated with each blink, after topical use of travoprost for 7 years.
AB - The prostaglandin analogues (PGAs), latanoprost, bimatoprost and travoprost have significantly changed the pharmacological management of glaucoma and ocular hypertension. Based on their good efficacy with only once daily dosing, and their low rate of systemic side effects, they are currently the mainstay of treatment.1 Therefore, it is important that medical practitioners are aware of their potential adverse effects. Conjunctival hyperaemia, iris pigmentation, hypertrichosis, periocular skin pigmentation, cystoid macular oedema, iris cysts, deepening of the upper eyelid sulci, sunken eye appearance and periorbital fat atrophy have been reported.2-4 Kucukevcilioglu et al. published their observations of 105 patients treated with PGAs in one eye for more than 1 month. The rate of prostaglandin‐associated periorbitopathy was 93.3%, 41.4% and 70% in the bimatoprost, latanoprost and travoprost groups.4 An Australian group recently reported audible blinking after topical bimatoprost for 3 years followed by travoprost 0.0004%/timolol 0.5% for 2 years.5 In this study, we present a case with clearly audible clicking sounds from both eyelids associated with each blink, after topical use of travoprost for 7 years.
KW - Glaucoma
KW - prostaglandin analogues
KW - ocular hypertension
KW - eyelids
KW - clicking
UR - http://www.scopus.com/inward/record.url?scp=85006459360&partnerID=8YFLogxK
U2 - 10.1111/ceo.12865
DO - 10.1111/ceo.12865
M3 - Letter
SN - 1442-6404
VL - 45
SP - 304
EP - 306
JO - Clinical and Experimental Ophthalmology
JF - Clinical and Experimental Ophthalmology
IS - 3
ER -