Australian and New Zealand recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion in the 3e Initiative

Scott Graf, Samuel Whittle, Mihir Wechalekar, John Moi, Claire Barrett, Catherine Hill, Geoff Littlejohn, Nora Lynch, Gabor Major, Andrew Taylor, Rachelle Buchbinder, Jane Zochling

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Abstract

    Aim: To develop evidence-based recommendations for the diagnosis and management of gout in Australia and New Zealand as part of the multi-national 3e Initiative. Method: Using a formal voting process, a panel of 78 international rheumatologists selected 10 key clinical questions pertinent to the diagnosis and management of gout. An additional question was also developed by participating Australian and New Zealand rheumatologists. Each question was investigated with a systematic literature review. MEDLINE, EMBASE, Cochrane CENTRAL and abstracts from 2010 to 2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis and risk of bias assessment. Using this evidence, 47 Australian and New Zealand rheumatologists developed national recommendations. For each recommendation the level of agreement was assessed and the level of evidence graded. Result: Eleven recommendations were produced relating to the diagnosis of gout, different aspects of the management of gout, cardiovascular and renal comorbidities and the management of asymptomatic hyperuricemia. The mean level of agreement with the recommendations was 9.1 on a 1-10 scale, with 10 representing full agreement. Conclusion: Eleven Australian and New Zealand recommendations on the diagnosis and management of gout were developed combining systematically reviewed evidence with local expertise, enhancing their utility in clinical practice.

    Original languageEnglish
    Pages (from-to)341-351
    Number of pages11
    JournalInternational Journal of Rheumatic Diseases
    Volume18
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2015

    Keywords

    • Drug treatment metabolic and crystal arthropathies
    • Metabolic and crystal arthropathies

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