Australian clinical practice guidelines for the diagnosis and management of Barrett’s esophagus and early esophageal adenocarcinoma

David Whiteman, Mark Appleyard, Farzan Bahin, Yuri Bobryshev, Michael Bourke, Ian Brown, Adrian Chung, Andrew Clouston, Emma Dickins, Jon Emery, Guy Eslick, Louisa Gordon, Florian Grimpen, Geoffrey Hebbard, Laura Holliday, Luke Hourigan, Bradley J Kendall, Eric Lee, Angelique Levert-Mignon, Reginald LordSarah Lord, Derek Maule, Alan Moss, Ian Norton, Ian Olver, Darren Pavey, Spiro Raftopoulos, Shan Rajendra, Mark Schoeman, Rajvinder Singh, Freddy Sitas, Mark Smithers, Andrew Taylor, Melissa Thomas, Iain Thomson, Henry To, Jutta Von Dincklage, Christine Vuletich, David Watson, Ian Yusoff

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances in knowledge and practice about the management of BE and early EAC. To aid clinical decision making in this rapidly moving field, Cancer Council Australia convened an expert working party to identify pertinent clinical questions. The questions covered a wide range of topics including endoscopic and histological definitions of BE and early EAC; prevalence, incidence, natural history, and risk factors for BE; and methods for managing BE and early EAC. The latter considered modification of lifestyle factors; screening and surveillance strategies; and medical, endoscopic, and surgical interventions. To answer each question, the working party systematically reviewed the literature and developed a set of recommendations through consensus. Evidence underpinning each recommendation was rated according to quality and applicability.

Original languageEnglish
Pages (from-to)804-820
Number of pages17
JournalJournal of Gastroenterology and Hepatology
Issue number5
Publication statusPublished - 1 May 2015


  • Barrett's esophagus
  • Clinical practice
  • Esophageal adenocarcinoma
  • Guidelines


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