Author Response: Stronger Association of CDKN2B-AS1 Variants in Female Normal-Tension Glaucoma Patients in a Japanese Population

Kathryn Burdon; Soo Ng; Stuart Macgregor; Jamie Craig

doi:10.1167/iovs.16-20917

Author Response: Stronger Association of CDKN2B-AS1 Variants in Female Normal-Tension Glaucoma Patients in a Japanese Population

Kathryn Burdon, Soo Ng, Stuart Macgregor, Jamie Craig

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Abstract

We read with great interest the letter to the editor by Mori et al. entitled “Stronger Association of CDKN2B-AS1 Variants in Female Normal-Tension Glaucoma Patients in a Japanese Population.” As pointed out in our original publication, the robust replication of genetic findings in independent populations is vital in understanding the significance of any reported association. Mori et al. have provided strong additional evidence for a sex-biased association with primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) at this locus. This finding vastly improves confidence in the results in our original report.

Original language	English
Pages (from-to)	6418-6418
Number of pages	1
Journal	Investigative Ophthalmology and Visual Science
Volume	57
Issue number	14
DOIs	https://doi.org/10.1167/iovs.16-20917
Publication status	Published - Nov 2016

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords

genetic
replication
sex-biased
Glaucoma

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abstract = "We read with great interest the letter to the editor by Mori et al. entitled “Stronger Association of CDKN2B-AS1 Variants in Female Normal-Tension Glaucoma Patients in a Japanese Population.” As pointed out in our original publication, the robust replication of genetic findings in independent populations is vital in understanding the significance of any reported association. Mori et al. have provided strong additional evidence for a sex-biased association with primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) at this locus. This finding vastly improves confidence in the results in our original report.",

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AU - Macgregor, Stuart

AU - Craig, Jamie

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