Abstract
We thank Dr Kawada for the interest and comment on our article: ‘Antidepressant use in late gestation and risk of postpartum haemorrhage: a retrospective cohort study’.1
Although we only reported on outcomes following exposure to any antidepressant type overall, we did collect data on the type of antidepressant exposure. Out of the 558 women exposed to antidepressants, 435 were exposed to selective serotonin reuptake inhibitors (SSRIs), 64 were exposed to serotonin norepinephrine reuptake inhibitors (SNRIs), and the remainder (n = 59) were exposed to other antidepressants.1 When classified according to serotonin reuptake inhibition, 542 women were exposed to serotonin reuptake inhibitors (SRIs), and just 16 women were exposed to non‐SRIs. Compared with women with a non‐medicated psychiatric illness, the unadjusted risk of postpartum haemorrhage (PPH) was increased following the use of SSRIs (relative risk, RR 1.46; 95% confidence interval, 95% CI 1.12–1.91) and SNRIs (RR 1.88; 95% CI 1.13–3.11), as well as SRIs (RR 1.46; 95% CI 1.20–1.77) and non‐SRI antidepressants (RR 2.23; 95% CI 0.97–5.30).
Although we only reported on outcomes following exposure to any antidepressant type overall, we did collect data on the type of antidepressant exposure. Out of the 558 women exposed to antidepressants, 435 were exposed to selective serotonin reuptake inhibitors (SSRIs), 64 were exposed to serotonin norepinephrine reuptake inhibitors (SNRIs), and the remainder (n = 59) were exposed to other antidepressants.1 When classified according to serotonin reuptake inhibition, 542 women were exposed to serotonin reuptake inhibitors (SRIs), and just 16 women were exposed to non‐SRIs. Compared with women with a non‐medicated psychiatric illness, the unadjusted risk of postpartum haemorrhage (PPH) was increased following the use of SSRIs (relative risk, RR 1.46; 95% confidence interval, 95% CI 1.12–1.91) and SNRIs (RR 1.88; 95% CI 1.13–3.11), as well as SRIs (RR 1.46; 95% CI 1.20–1.77) and non‐SRI antidepressants (RR 2.23; 95% CI 0.97–5.30).
| Original language | English |
|---|---|
| Pages (from-to) | 1284-1285 |
| Number of pages | 2 |
| Journal | BJOG: An International Journal of Obstetrics and Gynaecology |
| Volume | 124 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jul 2017 |
| Externally published | Yes |
Keywords
- Antidepressive agents/adverse effects
- late gestation
- postpartum hemorrhage
- retrospective cohort analysis
- selective serotonin reuptake inhibitors
- serotonin norepinephrine reuptake inhibitors (SNRIs)