Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

Diego G. Silva; Luis Socha; Brett Charlton; William Cowden; Nikolai Petrovsky

doi:10.1196/annals.1288.018

Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

Diego G. Silva, Luis Socha, Brett Charlton, William Cowden, Nikolai Petrovsky

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1005
DOIs	https://doi.org/10.1196/annals.1288.018
Publication status	Published - 1 Nov 2003
Externally published	Yes

Keywords

Apoptosis
Autoimmunity
Fas ligand
NOD
Type 1 diabetes

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AU - Silva, Diego G.

AU - Socha, Luis

AU - Charlton, Brett

AU - Cowden, William

AU - Petrovsky, Nikolai

PY - 2003/11/1

Y1 - 2003/11/1

N2 - Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

AB - Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

KW - Apoptosis

KW - Autoimmunity

KW - Fas ligand

KW - NOD

KW - Type 1 diabetes

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

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Keywords

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