Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

Diego G. Silva, Luis Socha, Brett Charlton, William Cowden, Nikolai Petrovsky

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1005
DOIs
Publication statusPublished - 1 Nov 2003
Externally publishedYes

Keywords

  • Apoptosis
  • Autoimmunity
  • Fas ligand
  • NOD
  • Type 1 diabetes

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