Azathioprine

Justine R Smith

doi:10.1007/978-3-540-75387-2_22

Azathioprine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Azathioprine is a synthetic purine analog. Although the drug has been used in clinical practice for approximately 50 years, the mechanism of immunosuppressive action remains poorly understood. In the late 1960s, the use of azathioprine to manage uveitis was first suggested. Subsequently, multiple case series and two randomized, placebo-controlled clinical trials have been published in support of the usefulness of this medication in patients with inflammatory eye disease.

Original language	English
Title of host publication	Intraocular Inflammation
Editors	Manfred Zierhut, Carlos Pavesio, Shigeaki Ohno, Fernando Orefice, Narsing A. Rao
Publisher	Springer
Chapter	22
Pages	309-314
Number of pages	6
ISBN (Electronic)	9783540753872
ISBN (Print)	9783540753858
DOIs	https://doi.org/10.1007/978-3-540-75387-2_22
Publication status	Published - 2016

Keywords

pharmacokinetics
immunosuppressive action
uveitis

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abstract = "Azathioprine is a synthetic purine analog. Although the drug has been used in clinical practice for approximately 50 years, the mechanism of immunosuppressive action remains poorly understood. In the late 1960s, the use of azathioprine to manage uveitis was first suggested. Subsequently, multiple case series and two randomized, placebo-controlled clinical trials have been published in support of the usefulness of this medication in patients with inflammatory eye disease.",

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AB - Azathioprine is a synthetic purine analog. Although the drug has been used in clinical practice for approximately 50 years, the mechanism of immunosuppressive action remains poorly understood. In the late 1960s, the use of azathioprine to manage uveitis was first suggested. Subsequently, multiple case series and two randomized, placebo-controlled clinical trials have been published in support of the usefulness of this medication in patients with inflammatory eye disease.

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KW - uveitis

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UR - http://purl.org/au-research/grants/ARC/FT130101648

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SP - 309

EP - 314

BT - Intraocular Inflammation

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A2 - Pavesio, Carlos

A2 - Ohno, Shigeaki

A2 - Orefice, Fernando

A2 - Rao, Narsing A.

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ER -

Azathioprine

Abstract

Keywords

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