Abstract
Objective: To document a case of azathioprine hepatotoxicity confirmed by rechallenge. Clinical features: A 50-year-old female with nodular scleritis of her left eye was treated with azathioprine as a steroid sparing agent. Agent four weeks liver transaminase concentrations increased and azathioprine was ceased. Azathioprine was recommenced after liver enzymes normalised. Signs and symptoms of hepatotoxicity recurred within 3 days and resolved rapidly after cessation of azathioprine. Conclusion: Azathioprine rechallenge in a patient who has experienced initial hepatotoxicity may lead to recurrence which is potentially more severe.
Original language | English |
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Pages (from-to) | 58-59 |
Number of pages | 2 |
Journal | Australian Journal of Hospital Pharmacy |
Volume | 30 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2000 |