Azathioprine hepatotoxicity confirmed by rechallenge

Vaughn S. Eaton; Jenny M. Casanova; Ann Kupa

doi:10.1002/jppr200030258

Azathioprine hepatotoxicity confirmed by rechallenge

Vaughn S. Eaton
, Jenny M. Casanova
, Ann Kupa

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: To document a case of azathioprine hepatotoxicity confirmed by rechallenge. Clinical features: A 50-year-old female with nodular scleritis of her left eye was treated with azathioprine as a steroid sparing agent. Agent four weeks liver transaminase concentrations increased and azathioprine was ceased. Azathioprine was recommenced after liver enzymes normalised. Signs and symptoms of hepatotoxicity recurred within 3 days and resolved rapidly after cessation of azathioprine. Conclusion: Azathioprine rechallenge in a patient who has experienced initial hepatotoxicity may lead to recurrence which is potentially more severe.

Original language	English
Pages (from-to)	58-59
Number of pages	2
Journal	Australian Journal of Hospital Pharmacy
Volume	30
Issue number	2
DOIs	https://doi.org/10.1002/jppr200030258
Publication status	Published - Apr 2000

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title = "Azathioprine hepatotoxicity confirmed by rechallenge",

abstract = "Objective: To document a case of azathioprine hepatotoxicity confirmed by rechallenge. Clinical features: A 50-year-old female with nodular scleritis of her left eye was treated with azathioprine as a steroid sparing agent. Agent four weeks liver transaminase concentrations increased and azathioprine was ceased. Azathioprine was recommenced after liver enzymes normalised. Signs and symptoms of hepatotoxicity recurred within 3 days and resolved rapidly after cessation of azathioprine. Conclusion: Azathioprine rechallenge in a patient who has experienced initial hepatotoxicity may lead to recurrence which is potentially more severe.",

author = "Eaton, \{Vaughn S.\} and Casanova, \{Jenny M.\} and Ann Kupa",

year = "2000",

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AU - Eaton, Vaughn S.

AU - Casanova, Jenny M.

AU - Kupa, Ann

PY - 2000/4

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N2 - Objective: To document a case of azathioprine hepatotoxicity confirmed by rechallenge. Clinical features: A 50-year-old female with nodular scleritis of her left eye was treated with azathioprine as a steroid sparing agent. Agent four weeks liver transaminase concentrations increased and azathioprine was ceased. Azathioprine was recommenced after liver enzymes normalised. Signs and symptoms of hepatotoxicity recurred within 3 days and resolved rapidly after cessation of azathioprine. Conclusion: Azathioprine rechallenge in a patient who has experienced initial hepatotoxicity may lead to recurrence which is potentially more severe.

AB - Objective: To document a case of azathioprine hepatotoxicity confirmed by rechallenge. Clinical features: A 50-year-old female with nodular scleritis of her left eye was treated with azathioprine as a steroid sparing agent. Agent four weeks liver transaminase concentrations increased and azathioprine was ceased. Azathioprine was recommenced after liver enzymes normalised. Signs and symptoms of hepatotoxicity recurred within 3 days and resolved rapidly after cessation of azathioprine. Conclusion: Azathioprine rechallenge in a patient who has experienced initial hepatotoxicity may lead to recurrence which is potentially more severe.

UR - https://www.scopus.com/pages/publications/0034107335

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DO - 10.1002/jppr200030258

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VL - 30

SP - 58

EP - 59

JO - Australian Journal of Hospital Pharmacy

JF - Australian Journal of Hospital Pharmacy

IS - 2

ER -

Azathioprine hepatotoxicity confirmed by rechallenge

Abstract

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