Bacillus cereus bacteremia and multiple brain abscesses during acute lymphoblastic leukemia induction therapy

Jordan Hansford, Marianne Phillips, Catherine Cole, Joshua Francis, Christopher Blyth, Nicholas Gottardo

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Bacillus cereus can cause serious infections in immunosuppressed patients. This population may be susceptible to B. cereus pneumonia, bacteremia, cellulitis, and rarely cerebral abscess. Here we report an 8-year-old boy undergoing induction therapy for acute lymphoblastic leukemia who developed multifocal B. cereus cerebral abscesses, highlighting the propensity for B. cereus to develop cerebral abscesses. A review of the literature over the past 25 years identified another 11 cases (3 children and 8 adults) of B. cereus cerebral abscess in patients undergoing cancer therapy. B. cereus cerebral abscesses were associated with a high mortality rate (42%) and significant morbidity. Notably, B. cereus bacteremia with concomitant cerebral abscess was associated with induction chemotherapy for acute leukemia in both children and adults (10 of 12 case reports). Our case report and review of the literature highlights the propensity for B. cereus to develop cerebral abscess(es). Therefore, early consideration for neuroimaging should be given for any neutropenic cancer patient identified with B. cereus bacteremia, in particular those with acute leukemia during induction therapy.

    Original languageEnglish
    Pages (from-to)e197-e201
    Number of pages5
    JournalJournal of Pediatric Hematology/Oncology
    Volume36
    Issue number3
    DOIs
    Publication statusPublished - Apr 2014

    Keywords

    • chemotherapy
    • oncology
    • opportunistic infection
    • Pediatrics

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