Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

D R Curtis; B D Gynther; D T Beattie; D I B Kerr; R H Prager

doi:10.1016/0304-3940(88)90749-5

Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

D R Curtis, B D Gynther, D T Beattie, D I B Kerr, R H Prager

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Neuroscience letters
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(88)90749-5
Publication status	Published - 23 Sept 1988

Keywords

2-Hydroxy-saclofen
Baclofen
Cat spinal cord
Primary afferent excitation

Access to Document

10.1016/0304-3940(88)90749-5Licence: In Copyright

Cite this

@article{1e43b62f05b54a5eab5ddb99a822ab76,

title = "Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord",

abstract = "When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.",

keywords = "2-Hydroxy-saclofen, Baclofen, Cat spinal cord, Primary afferent excitation",

author = "Curtis, {D R} and Gynther, {B D} and Beattie, {D T} and Kerr, {D I B} and Prager, {R H}",

year = "1988",

month = sep,

day = "23",

doi = "10.1016/0304-3940(88)90749-5",

language = "English",

volume = "92",

pages = "97--101",

journal = "Neuroscience letters",

issn = "0304-3940",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

AU - Curtis, D R

AU - Gynther, B D

AU - Beattie, D T

AU - Kerr, D I B

AU - Prager, R H

PY - 1988/9/23

Y1 - 1988/9/23

N2 - When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.

AB - When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.

KW - 2-Hydroxy-saclofen

KW - Baclofen

KW - Cat spinal cord

KW - Primary afferent excitation

UR - http://www.scopus.com/inward/record.url?scp=0023759675&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(88)90749-5

DO - 10.1016/0304-3940(88)90749-5

M3 - Article

C2 - 2847093

AN - SCOPUS:0023759675

SN - 0304-3940

VL - 92

SP - 97

EP - 101

JO - Neuroscience letters

JF - Neuroscience letters

IS - 1

ER -

Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this