Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

D R Curtis; B D Gynther; D T Beattie; D I B Kerr; R H Prager

doi:10.1016/0304-3940(88)90749-5

Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

D R Curtis, B D Gynther, D T Beattie, D I B Kerr, R H Prager

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70 Citations (Scopus)

Abstract

When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.

Original language	English
Pages (from-to)	97-101
Number of pages	5
Journal	Neuroscience letters
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(88)90749-5
Publication status	Published - 23 Sept 1988

Keywords

2-Hydroxy-saclofen
Baclofen
Cat spinal cord
Primary afferent excitation

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T1 - Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

AU - Curtis, D R

AU - Gynther, B D

AU - Beattie, D T

AU - Kerr, D I B

AU - Prager, R H

PY - 1988/9/23

Y1 - 1988/9/23

N2 - When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.

AB - When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. This compound, 2-hydroxy-saclofen, may be useful in assessing the physiological significance of central baclofen receptors.

KW - 2-Hydroxy-saclofen

KW - Baclofen

KW - Cat spinal cord

KW - Primary afferent excitation

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Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

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Keywords

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