Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood

Danielle Butzbach, Peter Stockham, Hilton Kobus, Donald Sims, Roger Byard, Robert Lokan, George Walker

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high-performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole-cleaved degradation products for both drugs were identified as 2-hydroxybenzoyl-risperidone and 2-hydroxybenzoyl-paliperidone utilizing liquid chromatography quadrupole-time-of-flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.

    Original languageEnglish
    Pages (from-to)90-100
    Number of pages11
    JournalJournal of Forensic Sciences
    Volume58
    Issue number1
    DOIs
    Publication statusPublished - Jan 2013

    Keywords

    • 2-hydroxybenzoyl-paliperidone
    • 2-hydroxybenzoyl-risperidone
    • Forensic science
    • Forensic toxicology
    • Paliperidone
    • Putrefaction
    • Risperidone

    Fingerprint Dive into the research topics of 'Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood'. Together they form a unique fingerprint.

    Cite this