Bacterial porins

R. E W Hancock; M. H. Brown

Bacterial porins

Research output: Contribution to journal › Review article › peer-review

Abstract

The outer membranes of Gram-negative bacteria are size dependent molecular sieves. Permeation of hydrophilic molecules below a certain exclusion limit occurs through the water-filled channels of a class of proteins called porins. Porins control the influx of nutrients and the efflux of metabolites and constitute a permeation barrier against certain antibiotics and other noxious chemicals. They protect pathogenic organisms from host defence factors. Porins are now well understood due to their relative ease of purification and subsequent examination in model membrane systems.

Original language	English
Pages (from-to)	24-32
Number of pages	9
Journal	Today's Life Science
Volume	4
Issue number	11
Publication status	Published - 1 Jan 1992
Externally published	Yes

Keywords

Bacterial Outer Membrane Proteins
Cephalosporins
Gram-Negative Bacteria

Cite this

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AB - The outer membranes of Gram-negative bacteria are size dependent molecular sieves. Permeation of hydrophilic molecules below a certain exclusion limit occurs through the water-filled channels of a class of proteins called porins. Porins control the influx of nutrients and the efflux of metabolites and constitute a permeation barrier against certain antibiotics and other noxious chemicals. They protect pathogenic organisms from host defence factors. Porins are now well understood due to their relative ease of purification and subsequent examination in model membrane systems.

KW - Bacterial Outer Membrane Proteins

KW - Cephalosporins

KW - Gram-Negative Bacteria

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JO - Today's Life Science

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Bacterial porins

Abstract

Keywords

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