Barrett's esophagus

Wayne Phillips, Reginald Lord, Derek Nancarrow, David Watson, David Whiteman

    Research output: Contribution to journalArticlepeer-review

    41 Citations (Scopus)

    Abstract

    Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium. While in itself a benign and asymptomatic disorder, the clinical importance of this relatively common condition relates to its role as a precursor lesion to esophageal adenocarcinoma, the incidence of which has dramatically increased in Western populations in recent years. Although known to arise as a consequence of chronic gastroesophageal reflux, the cellular and molecular mechanisms underlying development Barrett's esophagus and its progression to cancer remain unclear.

    Original languageEnglish
    Pages (from-to)639-648
    Number of pages10
    JournalJournal of Gastroenterology and Hepatology
    Volume26
    Issue number4
    DOIs
    Publication statusPublished - Apr 2011

    Keywords

    • Barrett's esophagus
    • Esophageal adenocarcinoma
    • Esophageal epithelium
    • Intestinal metaplasia

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