Barx Homeobox Family in Muscle Development and Regeneration

Helen Makarenkova, Robyn Meech

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    10 Citations (Scopus)

    Abstract

    Homeobox transcription factors are key intrinsic regulators of myogenesis. In studies spanning several years, we have characterized the homeobox factor Barx2 as a novel marker for muscle progenitor cells and an important regulator of muscle growth and repair. In this review, we place the expression and function of Barx2 and its paralogue Barx1 in context with other muscle-expressed homeobox factors in both embryonic and adult myogenesis. We also describe the structure and regulation of Barx genes and possible gene/disease associations. The functional domains of Barx proteins, their molecular interactions, and cellular functions are presented with particular emphasis on control of genes and processes involved in myogenic differentiation. Finally, we describe the patterns of Barx gene expression in vivo and the phenotypes of various Barx gene perturbation models including null mice. We focus on the Barx2 null mouse model, which has demonstrated the critical roles of Barx2 in postnatal myogenesis including muscle maintenance during aging, and regeneration of acute and chronic muscle injury.

    Original languageEnglish
    Title of host publicationInternational Review of Cell and Molecular Biology
    PublisherElsevier
    Pages117-173
    Number of pages57
    Volume297
    Edition1st
    ISBN (Print)9780123943088
    DOIs
    Publication statusPublished - 2012

    Publication series

    NameInternational Review of Cell and Molecular Biology
    Volume297
    ISSN (Print)1937-6448

    Keywords

    • Barx1
    • Barx2
    • Homeobox transcription factors
    • MRFs
    • Muscle regeneration
    • Pax7
    • Satellite cells
    • Stem cells

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