Bedside–to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria

Pupalan Iyngkaran, M Thomas

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Congestive heart failure (CHF) is a chronic condition usually without cure. Significant developments, particularly those addressing pathophysiology, mainly started at the bench. This approach has seen many clinical observations initially explored at the bench, subsequently being trialed at the bedside, and eventually translated into clinical practice. This evidence, however, has several limitations, importantly the generalizability or exter-nal validity. We now acknowledge that clinical management of CHF is more complicated than merely translating bench-to-bedside evidence in a linear fashion. This review aims to help explore this evolving area from an Australian perspective. We describe the continuation of research once core evidence is established and describe how clinician–scientist collaboration with a bedside-to-bench view can help enhance evidence translation and generalizability. We describe why an extension of the available evidence or generating new evidence is occasionally needed to address the increasingly diverse cohort of patients. Finally, we explore some of the tools used by basic scientists and clinicians to develop evidence and describe the ones we feel may be most beneficial.

    Original languageEnglish
    Pages (from-to)121-132
    Number of pages12
    JournalClinical Medicine Insights: Cardiology
    Volume9
    Issue numberS1
    DOIs
    Publication statusPublished - 25 Mar 2015

    Keywords

    • Bedside to bench
    • Comorbidities
    • Heart failure
    • Indigenous Australians
    • Translational research
    • Validity

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