Bioactive Mimetics of Conotoxins and other Venom Peptides

Peter Duggan, Kellie Tuck

    Research output: Contribution to journalReview article

    17 Citations (Scopus)

    Abstract

    Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include a description of how some of the initially designed mimics have been modified to improve their drug-like properties.

    Original languageEnglish
    Pages (from-to)4175-4198
    Number of pages24
    JournalToxins
    Volume7
    Issue number10
    DOIs
    Publication statusPublished - 16 Oct 2015

    Keywords

    • Ca 2.2
    • Conotoxins
    • N-type calcium channel
    • Peptidomimetics
    • Toxins
    • Venom peptides

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