Bioactive plasma coatings on orthodontic brackets: In vitro metal ion release and cytotoxicity

Lasni Samalka Kumarasinghe, Neethu Ninan, Panthihage Ruvini Lakshika Dabare, Alex Cavallaro, Esma J. Doğramacı, Giampiero Rossi-Fedele, Craig Dreyer, Krasimir Vasilev, Peter Zilm

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
21 Downloads (Pure)


The metal ion release characteristics and biocompatibility of meta-based materials are key factors that influence their use in orthodontics. Although stainless steel-based alloys have gained much interest and use due to their mechanical properties and cost, they are prone to localised attack after prolonged exposure to the hostile oral environment. Metal ions may induce cellular toxicity at high dosages. To circumvent these issues, orthodontic brackets were coated with a functional nano-thin layer of plasma polymer and further immobilised with enantiomers of tryptophan. Analysis of the physicochemical properties confirmed the presence of functional coatings on the surface of the brackets. The quantification of metal ion release using mass spectrometry proved that plasma functionalisation could minimise metal ion release from orthodontic brackets. Furthermore, the biocompatibility of the brackets has been improved after functionalisation. These findings demon-strate that plasma polymer facilitated surface functionalisation of orthodontic brackets is a promising approach to reducing metal toxicity without impacting their bulk properties.

Original languageEnglish
Article number857
Number of pages11
Issue number7
Publication statusPublished - Jul 2021
Externally publishedYes


  • Amino acid
  • Biocompatibility
  • Metal ion release
  • Orthodontic brackets
  • Plasma polymerisation


Dive into the research topics of 'Bioactive plasma coatings on orthodontic brackets: In vitro metal ion release and cytotoxicity'. Together they form a unique fingerprint.

Cite this