Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

D. M. Bowen, S. J. Allen, J. S. Benton, M. J. Goodhardt, E. A. Haan, A. M. Palmer, N. R. Sims, C. C.T. Smith, J. A. Spillane, M. M. Esiri, D. Neary, J. S. Snowdon, G. K. Wilcock, A. N. Davison

Research output: Contribution to journalArticlepeer-review

382 Citations (Scopus)


Abstract: Markers of serotonin synapses in entire temporal lobe and frontal and temporal neocortex were examined for changes in Alzheimer's disease by use of both neurosurgical and autopsy samples. Uptake of [3H]sero‐tonin, binding of [3H]imipramine, and content of indola‐mines were all significantly reduced, indicating that serotonin nerve terminals are affected. Binding of [3H]serotonin was also reduced, whereas that of [3H]qui‐nuclidinyl benzilate, [3H]muscimol, and [3H]dihydroal‐prenolol were unaltered. When the Alzheimer's samples were subdivided according to age, the reduction in [3H]serotonin binding was a feature of only autopsy samples from younger patients. In contrast, presynaptic cholinergic activity was reduced in all groups of Alzheimer's samples, including neurosurgical specimens. Five markers, thought to reflect cerebral atrophy, cytoplasm, nerve cell membrane, and neuronal perikarya were measured in the entire temporal lobe. In Alzheimer's disease the reductions (mean 25%, range 20–35%) were thought to be too large to be due only to loss of structures associated with the presumed cholinergic perikarya in the basal forebrain and monoamine neurones in the brain stem.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalJournal of Neurochemistry
Issue number1
Publication statusPublished - Jan 1983
Externally publishedYes


  • Acetylcholine
  • Alzheimer's disease
  • Atrophy
  • Neurotransmitter receptors
  • Serotonin


Dive into the research topics of 'Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease'. Together they form a unique fingerprint.

Cite this