Biocompatible anti-microbial coatings for urinary catheters

Vanessa Thompson, Penelope Adamson, Jessirie Dilag, Dhanushka Uswatte Liyanage, Kagithiri Srikantharajah, Andrew Blok, Amanda Ellis, David Gordon, Ingo Koper

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    7 Citations (Scopus)

    Abstract

    Using a simple dip-coating mechanism, urinary catheters have been coated with poly(2-methacryloyloxyethyl)trimethylammonium chloride (pMTAC) using activator regenerated by electron transfer (ARGET)-atom transfer radical polymerization (ATRP). A polydopamine-2-bromoisobutyryl bromide (pDA-BiBBr) initiator was initially grafted to the catheter surface to initiate polymerization resulting in a pDA-g-pMTAC coating. The pDA-g-pMTAC-coated catheters showed a significant reduction in bacterial adhesion, with respect to uncoated silicone catheters, as determined by analyzing microbiological assays as well as scanning electron microscopy images. At the same time, no evidence for cytotoxicity was observed, rather, the coating promoted cell adhesion and proliferation of human cells. This makes the coating attractive for temporary as well as permanently implanted medical devices.

    Original languageEnglish
    Pages (from-to)53303-53309
    Number of pages7
    JournalRSC Advances
    Volume6
    Issue number58
    DOIs
    Publication statusPublished - 2016

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  • Cite this

    Thompson, V., Adamson, P., Dilag, J., Uswatte Liyanage, D., Srikantharajah, K., Blok, A., Ellis, A., Gordon, D., & Koper, I. (2016). Biocompatible anti-microbial coatings for urinary catheters. RSC Advances, 6(58), 53303-53309. https://doi.org/10.1039/c6ra07678e