Biofluid Biomarkers of Amyotrophic Lateral Sclerosis

Cory Holden, Fred Steyn, Rob Henderson, Pam McCombe, Mary-Louise Rogers, Ngo Shyuan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Amyotrophic lateral sclerosis (ALS) is an adult-onset degenerative disease that is characterized by the progressive, irreversible loss of upper and lower motor neurons. It is a highly heterogeneous disease and variability in age of onset, site of onset, rate of disease progression, and survival between individuals present significant challenges for diagnosis and clinical care. Research into understanding the cause for ALS, and the clinical management of the disease is limited in part due to the absence of specific, sensitive biomarkers for the disease. To date, studies aimed at identifying reliable and specific biomarkers for ALS have revealed blood, cerebrospinal fluid (CSF), and urine markers as being useful. Here, we summarize some of the most promising fluid biomarkers identified to date, and discuss their proposed utility for improving our approach to ALS diagnosis, care, and research. Overall, while most studies into biomarkers for ALS explore single-marker utility, accurate profiling of individuals with ALS is likely to require a panel of complementary biomarkers providing insight into multiple aspects of the disease.
Original languageEnglish
Title of host publicationNeuromethods
Subtitle of host publicationTowards Translating Research to Clinical Practice
EditorsPhilip Peplow, Bridget Martinez, Thomas Gennarelli
PublisherSpringer
Chapter11
Pages263-306
Number of pages44
ISBN (Electronic)9781071617120
ISBN (Print)9781071617113, 9781071617144
DOIs
Publication statusE-pub ahead of print - 16 Oct 2021

Publication series

NameNeuromethods
Volume173
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Amyotrophic lateral sclerosis
  • Biomarkers
  • Neurofilaments
  • Inflammation
  • Metabolism
  • Oxidative stress
  • p75ECD

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