Biomarkers in motor neuron disease: A state of the art review

Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J.P. Alix, Iain D. Wilkinson, Tom M. Jenkins, Pamela J. Shaw

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous group of conditions, all of which are relentlessly progressive and ultimately fatal. The average life expectancy is 2 years, but with a broad range of months to decades. Biomarker research deepens disease understanding through exploration of pathophysiological mechanisms which, in turn, highlights targets for novel therapies. It also allows differentiation of the disease population into sub-groups, which serves two general purposes: (a) provides clinicians with information to better guide their patients in terms of disease progression, and (b) guides clinical trial design so that an intervention may be shown to be effective if population variation is controlled for. Biomarkers also have the potential to provide monitoring during clinical trials to ensure target engagement. This review highlights biomarkers that have emerged from the fields of systemic measurements including biochemistry (blood, cerebrospinal fluid, and urine analysis); imaging and electrophysiology, and gives examples of how a combinatorial approach may yield the best results. We emphasize the importance of systematic sample collection and analysis, and the need to correlate biomarker findings with detailed phenotype and genotype data.

Original languageEnglish
Article number291
Number of pages28
JournalFrontiers in Neurology
Volume10
Issue numberAPR
DOIs
Publication statusPublished - 3 Apr 2019
Externally publishedYes

Keywords

  • ALS (Amyotrophic lateral sclerosis)
  • Biofluid
  • Biomarker
  • Cerebrospinal fluid (CSF)
  • Electrophysiology
  • Motor neuron disease (MND)
  • Neuroimaging

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