Abstract
The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.
Original language | English |
---|---|
Pages (from-to) | 5162-5164 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 19 |
DOIs | |
Publication status | Published - 5 Oct 2012 |
Externally published | Yes |