Biomimetic total synthesis of (±)-garcibracteatone

Henry P. Pepper, Hiu C. Lam, Witold M. Bloch, Jonathan H. George

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.

Original languageEnglish
Pages (from-to)5162-5164
Number of pages3
JournalOrganic Letters
Volume14
Issue number19
DOIs
Publication statusPublished - 5 Oct 2012
Externally publishedYes

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