Biomonitoring of DNA damage in individuals exposed to brick kiln pollution from Peshawar, Khyber Pakhtunkhwa, Pakistan

Muhammad Khisroon; Ajmal Khan; Muhammad Imran; Farrah Zaidi; null Ahmadullah; Syeda Hira Fatima

doi:10.1080/19338244.2017.1304881

Biomonitoring of DNA damage in individuals exposed to brick kiln pollution from Peshawar, Khyber Pakhtunkhwa, Pakistan

Muhammad Khisroon, Ajmal Khan, Muhammad Imran, Farrah Zaidi, Ahmadullah, Syeda Hira Fatima

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Different kinds of harmful raw materials are used in brick kilns for baking bricks, thus exerting negative effects on the health of brick kiln workers and nearby residents. The comet assay technique monitors DNA damage in lymphocytes of brick kiln workers. Blood samples were collected from 150 participants to conduct comet assay. The results indicated a highly significant increase (p <.0001) in DNA damage in brick kiln workers (171.9 ± 62.1) as compared with the control group (101.9 ± 48.3). Duration of occupational exposure had positive correlation (r =.823, p <.05) with DNA damage. Age and tobacco use had significant effects on total comet score (TCS) of exposed group as compared to control group (p <.05). In summary, these findings indicate greater genotoxicity in brick kiln workers.

Original language	English
Pages (from-to)	115-120
Number of pages	6
Journal	Archives of Environmental and Occupational Health
Volume	73
Issue number	2
Early online date	5 Apr 2017
DOIs	https://doi.org/10.1080/19338244.2017.1304881
Publication status	Published - Mar 2018
Externally published	Yes

Keywords

Biomonitoring
brick kilns
brick kiln workers
comet assay
DNA damage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/19338244.2017.1304881Licence: In Copyright

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title = "Biomonitoring of DNA damage in individuals exposed to brick kiln pollution from Peshawar, Khyber Pakhtunkhwa, Pakistan",

abstract = "Different kinds of harmful raw materials are used in brick kilns for baking bricks, thus exerting negative effects on the health of brick kiln workers and nearby residents. The comet assay technique monitors DNA damage in lymphocytes of brick kiln workers. Blood samples were collected from 150 participants to conduct comet assay. The results indicated a highly significant increase (p <.0001) in DNA damage in brick kiln workers (171.9 ± 62.1) as compared with the control group (101.9 ± 48.3). Duration of occupational exposure had positive correlation (r =.823, p <.05) with DNA damage. Age and tobacco use had significant effects on total comet score (TCS) of exposed group as compared to control group (p <.05). In summary, these findings indicate greater genotoxicity in brick kiln workers.",

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author = "Muhammad Khisroon and Ajmal Khan and Muhammad Imran and Farrah Zaidi and Ahmadullah and Fatima, {Syeda Hira}",

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doi = "10.1080/19338244.2017.1304881",

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AU - Khisroon, Muhammad

AU - Khan, Ajmal

AU - Imran, Muhammad

AU - Zaidi, Farrah

AU - Ahmadullah, null

AU - Fatima, Syeda Hira

PY - 2018/3

Y1 - 2018/3

N2 - Different kinds of harmful raw materials are used in brick kilns for baking bricks, thus exerting negative effects on the health of brick kiln workers and nearby residents. The comet assay technique monitors DNA damage in lymphocytes of brick kiln workers. Blood samples were collected from 150 participants to conduct comet assay. The results indicated a highly significant increase (p <.0001) in DNA damage in brick kiln workers (171.9 ± 62.1) as compared with the control group (101.9 ± 48.3). Duration of occupational exposure had positive correlation (r =.823, p <.05) with DNA damage. Age and tobacco use had significant effects on total comet score (TCS) of exposed group as compared to control group (p <.05). In summary, these findings indicate greater genotoxicity in brick kiln workers.

AB - Different kinds of harmful raw materials are used in brick kilns for baking bricks, thus exerting negative effects on the health of brick kiln workers and nearby residents. The comet assay technique monitors DNA damage in lymphocytes of brick kiln workers. Blood samples were collected from 150 participants to conduct comet assay. The results indicated a highly significant increase (p <.0001) in DNA damage in brick kiln workers (171.9 ± 62.1) as compared with the control group (101.9 ± 48.3). Duration of occupational exposure had positive correlation (r =.823, p <.05) with DNA damage. Age and tobacco use had significant effects on total comet score (TCS) of exposed group as compared to control group (p <.05). In summary, these findings indicate greater genotoxicity in brick kiln workers.

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KW - brick kilns

KW - brick kiln workers

KW - comet assay

KW - DNA damage

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Biomonitoring of DNA damage in individuals exposed to brick kiln pollution from Peshawar, Khyber Pakhtunkhwa, Pakistan

Abstract

Keywords

UN SDGs

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