BK Virus Encoded MicroRNAs Are Present in Blood of Renal Transplant Recipients With BK Viral Nephropathy.

Jordan Li, Kym McNicholas, Tuck Yong, Nitesh Rao, P Coates, Geoffrey Higgins, Robert Carroll, Richard Woodman, Michael Michael, Jonathan Gleadle

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    BK viral infection is an important cause of renal transplant dysfunction and failure. Current strategies utilize surveillance for infection with DNA polymerase chain reaction assays and modulation of immunosuppression. Many viruses including polyomaviruses encode microRNAs (miRNAs). We have detected BK virus (BKV) encoded miRNAs in the blood of infected renal transplant recipients, and see a strong correlation between BKV encoded miRNA and BKV DNA in blood and a relationship between levels of bkv-miR-B1-5p and the presence of biopsy-proven BK viral nephropathy. Further research is needed to determine whether the detection of this and other virally encoded miRNAs may be useful in the diagnosis of active viral replication. The investigators examine for BK virus encoded microRNAs in the blood of renal transplant recipients and detect these microRNAs in patients with active BK virus nephropathy.

    Original languageEnglish
    Pages (from-to)1183-1190
    Number of pages8
    JournalAmerican Journal of Transplantation
    Volume14
    Issue number5
    DOIs
    Publication statusPublished - May 2014

    Keywords

    • BK nephropathy
    • BK virus
    • microRNA
    • renal transplant

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