Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

N A Lambert, N L Harrison, D I B Kerr, J Ong, R H Prager, T J Teyler

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potentials from CA1 hippocampal neurons. 2-Hydroxy-saclofen (50-200 μM) reversibly blocked the late, GABAB receptor-mediated inhibitory postsynaptic potential (IPSP) but not the early, GABAA receptor-mediated IPSP. In addition, the hyperpolarizing response to baclofen was reduced by similar concentrations of 2-hydroxy-saclofen. This suggests that 2-hydroxy-saclofen is a potent antagonist at postsynaptic GABAB receptors on hippocampal neurons.

    Original languageEnglish
    Pages (from-to)125-128
    Number of pages4
    JournalNeuroscience Letters
    Volume107
    Issue number1-3
    DOIs
    Publication statusPublished - 15 Dec 1989

    Keywords

    • 2-Hydroxy-saclofen
    • Rat hippocampal slice
    • Slow inhibitory postsynaptic potential
    • γ-Aminobutyric acid-B receptor

    Fingerprint

    Dive into the research topics of 'Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen'. Together they form a unique fingerprint.

    Cite this