Blood-borne viruses in the haemodialysis-dependent population attending Top End Northern Territory facilities 2000-2009.

Jane Davies, Zulfikar Jabbar, Fizza Gagan, Robert Baird

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)

    Abstract

    Aim: To describe the incidence and prevalence of blood-borne viruses (BBV) including: hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and human T-cell leukaemia virus type-1 (HTLV) in the haemodialysis-dependent population of the Top End of the Northern Territory (TENT). Methods: We retrospectively reviewed the serology of BBV in a longitudinal fashion in the haemodialysis-dependent population treated in the TENT of Australia from 2000 to 2009 inclusive. HBV, HCV, HIV and HTLV serology on commencement of dialysis and at exit or January 2010, whichever was earlier, as well as demographic details were collected. Patients with a change in serological status had all serology reviewed. Results: Four-hundred and forty patients were included in the analysis. Of these, 84.3% were Indigenous and 55.4% female, with a median age of 50 (IQR 43-59) years at the commencement of haemodialysis. Evidence of past HBV infection was documented in 42.7% and 8.9% were hepatitis B surface antigen-positive. Positive serology for HTLV was documented in 2.2%, 1.6% were hepatitis C antibody-positive and no individual was HIV-positive. Three patients had a definite change in their HBV serology over time; this equates to an absolute seroconversion risk of 0.1 per 100 person years or 0.0006 per dialysis episode. Conclusions: In this cohort, there was a high rate of past and current hepatitis B infection but low rates of seroconversion while on haemodialysis.

    Original languageEnglish
    Pages (from-to)501-507
    Number of pages7
    JournalNephrology
    Volume17
    Issue number5
    DOIs
    Publication statusPublished - Jul 2012

    Keywords

    • dialysis
    • hepatitis B
    • infection control
    • Northern Territory

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