TY - JOUR
T1 - Blood Cell Count Biomarkers, Risk, and Outcomes of Ischemia-Related Lower Limb Amputations
T2 - A Systematic Review
AU - Dettori, Paola
AU - Mangoni, Arduino
AU - Zinellu, Angelo
AU - Carru, Ciriaco
AU - Paliogiannis, Panagiotis
PY - 2022/12
Y1 - 2022/12
N2 - Lower limb amputations due to ischemia represent an important health care and social issue. However, there are currently no specific biomarkers able to predict the risk of amputation and postamputation complications and prognosis. We conducted a systematic review of studies investigating whether blood cell count indexes of systemic inflammation are linked to the risk and the outcome of lower limb amputations due to ischemia. Overall, in 22 studies involving 8832 patients selected for review, several blood cell count indexes, particularly the neutrophil lymphocyte ratio, showed some promise in terms of predicting amputations and general outcomes of conservative and surgical treatments, as well as postamputation complications and prognosis. However, largely due to methodological limitations, further prospective studies are required to establish the clinical utility and applicability of blood cell indexes in the routine management of patients with ischemia-related lower limb amputations.
AB - Lower limb amputations due to ischemia represent an important health care and social issue. However, there are currently no specific biomarkers able to predict the risk of amputation and postamputation complications and prognosis. We conducted a systematic review of studies investigating whether blood cell count indexes of systemic inflammation are linked to the risk and the outcome of lower limb amputations due to ischemia. Overall, in 22 studies involving 8832 patients selected for review, several blood cell count indexes, particularly the neutrophil lymphocyte ratio, showed some promise in terms of predicting amputations and general outcomes of conservative and surgical treatments, as well as postamputation complications and prognosis. However, largely due to methodological limitations, further prospective studies are required to establish the clinical utility and applicability of blood cell indexes in the routine management of patients with ischemia-related lower limb amputations.
KW - amputation
KW - lower limb
KW - ischemia
KW - blood cell indexes
KW - neutrophil lymphocyte ratio
UR - http://www.scopus.com/inward/record.url?scp=85092543403&partnerID=8YFLogxK
U2 - 10.1177/1534734620961785
DO - 10.1177/1534734620961785
M3 - Article
AN - SCOPUS:85092543403
SN - 1552-6941
VL - 21
SP - 354
EP - 363
JO - International Journal of Lower Extremity Wounds
JF - International Journal of Lower Extremity Wounds
IS - 4
ER -