TY - JOUR
T1 - Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis
AU - Zinellu, Angelo
AU - Paliogiannis, Panagiotis
AU - Sotgiu, Elisabetta
AU - Mellino, Sabrina
AU - Mangoni, Arduino A.
AU - Zinellu, Elisabetta
AU - Negri, Silvia
AU - Collu, Claudia
AU - Pintus, Gianfranco
AU - Serra, Antonello
AU - Pistuddi, Angelo Maria
AU - Carru, Ciriaco
AU - Pirina, Pietro
AU - Fois, Alessandro G.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Purpose: Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. Methods: Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this cross-sectional study. Results: We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression, all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed. Conclusions: In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF.
AB - Purpose: Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. Methods: Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this cross-sectional study. Results: We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression, all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed. Conclusions: In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF.
KW - Idiopathic pulmonary fibrosis
KW - Inflammation
KW - IPF
KW - LMR
KW - NLR
KW - PLR
UR - http://www.scopus.com/inward/record.url?scp=85089782090&partnerID=8YFLogxK
U2 - 10.1007/s00408-020-00386-7
DO - 10.1007/s00408-020-00386-7
M3 - Article
C2 - 32844257
AN - SCOPUS:85089782090
SN - 0341-2040
VL - 198
SP - 821
EP - 827
JO - Lung
JF - Lung
IS - 5
ER -