Blood cell count indexes of systemic inflammation in carotid artery disease: Current evidence and future perspectives

Paola Dettori, Panagiotis Paliogiannis, Rosa M. Pascale, Angelo Zinellu, Arduino A. Mangoni, Gianfranco Pintus

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Carotid artery disease is commonly encountered in clinical practice and accounts for approximately 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated as predictors of the onset and progression of carotid disease, the occurrence of cerebrovascular complications, and overall prognosis. Among them, blood cell count (BCC) indexes of systemic inflammation might be particularly useful, from a pathophysiological and clinical point of view, given the inflammatory nature of the atherosclerotic pro-cess. The aim of this review is to discuss the available evidence regarding the role of common BCC indexes, such as the neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW), in the diagnosis and risk stratification of carotid artery disease, and their potential clinical applications.

Original languageEnglish
Pages (from-to)2170-2179
Number of pages10
JournalCURRENT PHARMACEUTICAL DESIGN
Volume27
Issue number18
DOIs
Publication statusPublished - 2021

Keywords

  • Atherosclerosis
  • Carotid artery disease
  • MLR
  • MPV
  • NLR
  • PLR
  • RDW

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