Both Sample Number and Test Positivity Threshold Determine Colonoscopy Efficiency in Detection of Colorectal Cancer With Quantitative Fecal Immunochemical Tests

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Abstract

The fecal hemoglobin concentration varies between colorectal pathologies and between samples because bleeding is not consistent from day to day.1 Thus, when screening for colorectal cancer (CRC) using a quantitative fecal immunochemical test (FIT), the fecal hemoglobin concentration threshold (cutoff) chosen to trigger colonoscopy,2 together with the number of stools sampled, are crucial variables requiring careful selection, because of the implications for sensitivity, specificity, colonoscopic workload, and cost effectiveness.
Original languageEnglish
Pages (from-to)1561-1563.e3
Number of pages6
JournalGastroenterology
Volume159
Issue number4
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Colonoscopy Workload
  • Colorectal Cancer
  • Fecal Immunochemical Test
  • Modeling
  • Screening
  • Sensitivity

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