Both Sample Number and Test Positivity Threshold Determine Colonoscopy Efficiency in Detection of Colorectal Cancer With Quantitative Fecal Immunochemical Tests

Graeme P. Young; Richard J. Woodman; Fang L.I. Ang; Erin L. Symonds

doi:10.1053/j.gastro.2020.05.008

Both Sample Number and Test Positivity Threshold Determine Colonoscopy Efficiency in Detection of Colorectal Cancer With Quantitative Fecal Immunochemical Tests

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

108 Downloads (Pure)

Abstract

The fecal hemoglobin concentration varies between colorectal pathologies and between samples because bleeding is not consistent from day to day.1 Thus, when screening for colorectal cancer (CRC) using a quantitative fecal immunochemical test (FIT), the fecal hemoglobin concentration threshold (cutoff) chosen to trigger colonoscopy,2 together with the number of stools sampled, are crucial variables requiring careful selection, because of the implications for sensitivity, specificity, colonoscopic workload, and cost effectiveness.

Original language	English
Pages (from-to)	1561-1563.e3
Number of pages	6
Journal	Gastroenterology
Volume	159
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2020.05.008
Publication status	Published - Oct 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Colonoscopy Workload
Colorectal Cancer
Fecal Immunochemical Test
Modeling
Screening
Sensitivity

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10.1053/j.gastro.2020.05.008Licence: CC BY-NC-ND

Published versionFinal published version, 585 KBLicence: CC BY-NC-ND

Cite this

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title = "Both Sample Number and Test Positivity Threshold Determine Colonoscopy Efficiency in Detection of Colorectal Cancer With Quantitative Fecal Immunochemical Tests",

abstract = "The fecal hemoglobin concentration varies between colorectal pathologies and between samples because bleeding is not consistent from day to day.1 Thus, when screening for colorectal cancer (CRC) using a quantitative fecal immunochemical test (FIT), the fecal hemoglobin concentration threshold (cutoff) chosen to trigger colonoscopy,2 together with the number of stools sampled, are crucial variables requiring careful selection, because of the implications for sensitivity, specificity, colonoscopic workload, and cost effectiveness.",

keywords = "Colonoscopy Workload, Colorectal Cancer, Fecal Immunochemical Test, Modeling, Screening, Sensitivity",

author = "Young, \{Graeme P.\} and Woodman, \{Richard J.\} and Ang, \{Fang L.I.\} and Symonds, \{Erin L.\}",

year = "2020",

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doi = "10.1053/j.gastro.2020.05.008",

language = "English",

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T1 - Both Sample Number and Test Positivity Threshold Determine Colonoscopy Efficiency in Detection of Colorectal Cancer With Quantitative Fecal Immunochemical Tests

AU - Young, Graeme P.

AU - Woodman, Richard J.

AU - Ang, Fang L.I.

AU - Symonds, Erin L.

PY - 2020/10

Y1 - 2020/10

N2 - The fecal hemoglobin concentration varies between colorectal pathologies and between samples because bleeding is not consistent from day to day.1 Thus, when screening for colorectal cancer (CRC) using a quantitative fecal immunochemical test (FIT), the fecal hemoglobin concentration threshold (cutoff) chosen to trigger colonoscopy,2 together with the number of stools sampled, are crucial variables requiring careful selection, because of the implications for sensitivity, specificity, colonoscopic workload, and cost effectiveness.

AB - The fecal hemoglobin concentration varies between colorectal pathologies and between samples because bleeding is not consistent from day to day.1 Thus, when screening for colorectal cancer (CRC) using a quantitative fecal immunochemical test (FIT), the fecal hemoglobin concentration threshold (cutoff) chosen to trigger colonoscopy,2 together with the number of stools sampled, are crucial variables requiring careful selection, because of the implications for sensitivity, specificity, colonoscopic workload, and cost effectiveness.

KW - Colonoscopy Workload

KW - Colorectal Cancer

KW - Fecal Immunochemical Test

KW - Modeling

KW - Screening

KW - Sensitivity

UR - https://www.scopus.com/pages/publications/85092726276

U2 - 10.1053/j.gastro.2020.05.008

DO - 10.1053/j.gastro.2020.05.008

M3 - Article

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AN - SCOPUS:85092726276

SN - 0016-5085

VL - 159

SP - 1561-1563.e3

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Both Sample Number and Test Positivity Threshold Determine Colonoscopy Efficiency in Detection of Colorectal Cancer With Quantitative Fecal Immunochemical Tests

Abstract

UN SDGs

Keywords

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