Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

Cassandra Chaptini, Genevieve Casey, Adam G. Harris, David Wattchow, Lynne Gordon, Dedee F. Murrell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalInternational Journal of Women's Dermatology
Volume1
Issue number4
DOIs
Publication statusPublished - Dec 2015
Externally publishedYes

Bibliographical note

This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

  • dystrophic epidermolysis bullosa
  • anal fissures
  • botulinum toxin A

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