Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

Cassandra Chaptini; Genevieve Casey; Adam G. Harris; David Wattchow; Lynne Gordon; Dedee F. Murrell

doi:10.1016/j.ijwd.2015.08.002

Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

Cassandra Chaptini, Genevieve Casey, Adam G. Harris, David Wattchow, Lynne Gordon, Dedee F. Murrell

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

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Abstract

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.

Original language	English
Pages (from-to)	167-169
Number of pages	3
Journal	International Journal of Women's Dermatology
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/j.ijwd.2015.08.002
Publication status	Published - Dec 2015
Externally published	Yes

Bibliographical note

This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

dystrophic epidermolysis bullosa
anal fissures
botulinum toxin A

Access to Document

10.1016/j.ijwd.2015.08.002Licence: CC BY-NC-ND

Chaptini_Botulinum_P2015Final published version, 164 KBLicence: CC BY-NC-ND

Cite this

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title = "Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa",

abstract = "We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.",

keywords = "dystrophic epidermolysis bullosa, anal fissures, botulinum toxin A",

author = "Cassandra Chaptini and Genevieve Casey and Harris, {Adam G.} and David Wattchow and Lynne Gordon and Murrell, {Dedee F.}",

note = "This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

year = "2015",

month = dec,

doi = "10.1016/j.ijwd.2015.08.002",

language = "English",

volume = "1",

pages = "167--169",

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publisher = "Wolters Kluwer",

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T1 - Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

AU - Chaptini, Cassandra

AU - Casey, Genevieve

AU - Harris, Adam G.

AU - Wattchow, David

AU - Gordon, Lynne

AU - Murrell, Dedee F.

N1 - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PY - 2015/12

Y1 - 2015/12

N2 - We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.

AB - We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.

KW - dystrophic epidermolysis bullosa

KW - anal fissures

KW - botulinum toxin A

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JO - International Journal of Women's Dermatology

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Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

Abstract

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Keywords

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