Brain-derived neurotrophic factor gene polymorphisms and mirtazapine responses in Koreans with major depression

Rhee-Hun Kang, Hun Chang, Ma-Li Wong, Myoung-Jin Choi, Ji-Young Park, Hwa-Young Lee, In-Kwa Jung, Sook-Haeng Joe, Leen Kim, Seung-Hyun Kim, Yong-Ku Kim, Chang-Su Han, Byung-Joo Ham, Heon-Jeong Lee, Young-Hoon Ko, Moon-Soo Lee, Min-Soo Lee

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)


    Brain-derived neurotrophic factor (BDNF) is a candidate molecule for influencing the clinical response to antidepressant treatment. The aims of this study were to determine the relationship between the Val66Met polymorphism in the BDNF gene and the response to mirtazapine in 243 Korean subjects with major depressive disorder (MDD). The reduction in the Hamilton Depression score over the 8-week treatment period was not influenced by BDNF V66M genotypes. A marginal effect of genotype on somatic anxiety score was observed at baseline (P = 0.047 in the dominant model). However, genotype-time interaction had no effect on somatic anxiety score after the 8-week a treatment period. Plasma BDNF levels tended to increase during mirtazapine treatment, although without statistical significance (P = 0.055). After 8 weeks of mirtazapine treatment, plasma BDNF levels were higher in Met allele homozygotes (1499.7 ± 370.6 ng/mL) than in Val allele carriers (649.7 ± 158.5 ng/mL, P = 0.049). Our results do not support the hypothesis that the Val66Met promoter polymorphism in the BDNF gene influences the therapeutic response to mirtazapine in Korean MDD patients. However, our data indicate that this polymorphism results in increased plasma BDNF after mirtazapine treatment.

    Original languageEnglish
    Pages (from-to)1755-1763
    Number of pages9
    Issue number12
    Publication statusPublished - Dec 2010


    • brain-derived neurotrophic factor
    • gene polymorphisms
    • major depression
    • mirtazapine
    • treatment response


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