Abstract
Purpose
To explore changes in the electroretinogram (ERG) following methylphenidate use in attention-deficit/hyperactivity disorder (ADHD).
Methods
Light adapted ERGs were recorded in five individuals (3 male and 2 female, age range 13.6–21.8 years) with a diagnosis of ADHD. Six flash strengths ranging from 71 to 446 Td.s were qualitatively evaluated following a minimum of 24 h without any medication and from 2 to 6 h following the individuals’ standard slow-release (XL) methylphenidate dose that ranged from 18 to 60 mg.
Results
Of the six flash strengths, the 178 Td.s strength revealed changes in four of the five participants with a median 27.4% increase in b-wave amplitude. For three individuals there was an increase in the a-wave amplitude and for two of the same individuals there was also a noticeable pronouncement of the oscillatory potentials. The a-wave amplitude showed a greatest median increase at the 446 Td.s flash strength of 25.8%. One individual – on the highest dose (60 mg) exhibited no morphologically distinct changes in the ERG. No differences in the time to peaks of the a- and b-wave were observed for any individual.
Conclusion
The a- and b-wave amplitudes of the light adapted ERG could provide insights into the effect of methylphenidate in ADHD
To explore changes in the electroretinogram (ERG) following methylphenidate use in attention-deficit/hyperactivity disorder (ADHD).
Methods
Light adapted ERGs were recorded in five individuals (3 male and 2 female, age range 13.6–21.8 years) with a diagnosis of ADHD. Six flash strengths ranging from 71 to 446 Td.s were qualitatively evaluated following a minimum of 24 h without any medication and from 2 to 6 h following the individuals’ standard slow-release (XL) methylphenidate dose that ranged from 18 to 60 mg.
Results
Of the six flash strengths, the 178 Td.s strength revealed changes in four of the five participants with a median 27.4% increase in b-wave amplitude. For three individuals there was an increase in the a-wave amplitude and for two of the same individuals there was also a noticeable pronouncement of the oscillatory potentials. The a-wave amplitude showed a greatest median increase at the 446 Td.s flash strength of 25.8%. One individual – on the highest dose (60 mg) exhibited no morphologically distinct changes in the ERG. No differences in the time to peaks of the a- and b-wave were observed for any individual.
Conclusion
The a- and b-wave amplitudes of the light adapted ERG could provide insights into the effect of methylphenidate in ADHD
| Original language | English |
|---|---|
| Article number | e9 |
| Pages (from-to) | 25-32 |
| Number of pages | 8 |
| Journal | Documenta Ophthalmologica |
| Volume | 150 |
| Issue number | 1 |
| Early online date | 15 Dec 2024 |
| DOIs | |
| Publication status | Published - Feb 2025 |
Keywords
- Dopamine
- Attention deficit hyperactivity disorder
- Retina
- Medication