Butalactin, a New Butanolide Antibiotic: Taxonomy, fermentation, isolation and biological activity

Christopher M.M. Franco, Urmila P. Borde, E. K.S. Vijayakumar, Sugata Chatterjee, Jurgen Blumbach, Bimal N. Ganguli

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Butalactin, [2-(4′,5′-epoxy-hex-2′(E)-en)oyl-2-hydroxy-3-hydroxymethy1-2,3-(Z)-butanolide] is a new antibiotic produced by Streptomyces sp. HIL Y-86,36923. Taxonomically, the producing organism most closely resembles Streptomyces corchorusii. The strain also produces cineromycin B. Though butalactin is structurally related to ′signal molecules′ such as A-factor, the anthracycline inducing factors and the virginiae butanolides, it does not show inducing activity for antibiotic production or aerial mycelium formation in the indicator strain. Butalactin possesses a weak antibiotic activity against Gram-positive and Gram-negative bacteria.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalThe Journal of Antibiotics
Volume44
Issue number2
DOIs
Publication statusPublished - 1 Jan 1991
Externally publishedYes

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