C-FOS expression in central cardiovascular pathways

J. B. Minson, S. Suzuki, I. J. Llewellyn-Smith, P. M. Pilowsky, L. F. Arnolda, J. P. Chalmers

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.

    Original languageEnglish
    Pages (from-to)67-79
    Number of pages13
    JournalClinical and Experimental Hypertension
    Volume17
    Issue number1-2
    DOIs
    Publication statusPublished - 1995

    Keywords

    • Antisense oligonucleotides
    • Blood pressure
    • Fos
    • Rostral ventral medulla

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