Calcium and magnesium prophylaxis for oxaliplatin-related neurotoxicity: Is it a trade-off between drug efficacy and toxicity?

Muhammad Khattak

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Oxaliplatin-based chemotherapy regimens are the current standard treatment in the management of colorectal cancer. Neurotoxicity is the major cause of treatment delay, dose reduction, and cessation of oxaliplatin. Evidence regarding the role of calcium and magnesium prophylaxis to prevent oxaliplatin-related neurotoxicity is conflicting and further randomized data are needed to answer this question accurately. The purpose of this paper is to provide a critical overview of various studies that have been conducted so far to evaluate the preventative role of calcium and magnesium prophylaxis against oxaliplatin-related neurotoxicity.

    Original languageEnglish
    Pages (from-to)1780-1783
    Number of pages4
    JournalOncologist
    Volume16
    Issue number12
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Calcium
    • Colon cancer
    • Magnesium
    • Neuropathy
    • Oxaliplatin

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